Note: The concentration of catecholamines and their metabolites in plasma or brain are useful for diagnosis and evaluation of therapeutic and pharmacodynamic effects for psychiatric, neurological and cardiovascular disorders. The use of mass spectroscopy for detection in the analysis of catecholamines is an effective approach due to the lack of a suitable chromophore on these molecules making UV detection difficult. In addition mass spectrometry provides positive identification of each component. The analysis (total ion chromatogram) of a four-component catecholamine mixture on Cogent Bidentate C18 column is shown. Click here to view printable Application Sheet

Method Conditions