When to Perform PQ on HPLC

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When To Perform a PQ Test on your Instrument

Aside from regulatory issues, it is generally accepted that a Performance Qualification of any HPLC system should be done:

Every 6 to 12 Months
After any Preventative Maintenance
After any Upgrades
After any repairs
After moving any instrument
During Method Transfer and System Troubleshooting

It is also generally accepted that a PQ should be done by technicians and not by the repair or service person since you are ultimately validating the work they did. It is important to demonstrate that the work was done properly and that the original design specifications are still being met. If not, an IQ/OQ must be done first.

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