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Can Your HPLC Column Do This? Real Life Application The pharmaceutical formulation of the highly polar molecule, Metformin (LogP of minus 2.64) and the relatively non polar molecule Glyburide (LogP 4.79) and of interest to many Generic Pharmaceutical companies that are considering its analysis. Ideally a simple quick isocratic analysis is desired. But Metformin is so polar that when examined, its retention on the following Type B HPLC phases :HPS™ C18, hQ™ C8, Axis™ C18, Axis™ Phenyl, Cogent F5™, HPS™ Cyano or HPS™ Amino using Cogent Mini-Scout™ Strategy; Metformin was not retained in 100% aqueous, or buffered aqueous.
Then TYPE-C™ phases were examined.
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