Process HPLC Column, RP PFP, 10um, 100A. 50mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
68022-P50-100 Cogent RP PFP™ Process HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for process‑scale and production‑level purification. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These mechanisms improve separation efficiency and enable reliable purification of closely related compounds in large‑scale workflows.
With a 10 µm particle size, this column offers extremely low backpressure, allowing very high flow rates and excellent compatibility with large‑diameter process HPLC systems.
100 mm Length – Balanced Performance at Process Scale
The 100 mm length provides an optimal balance between resolution and throughput for production environments.
Improved resolution compared to 50 mm columns
Faster cycle times than longer process columns
Increased peak capacity for moderately complex mixtures
✅ Recommended for routine large‑scale purification and process development
Flow Rate & System Requirements (50 mm ID, 10 µm)
⚠️ Requires process‑scale or pilot‑scale HPLC system capability
Typical flow rate range: ~40 – 150 mL/min
Extremely low backpressure vs 5 µm and 3 µm columns
Designed for ultra high‑flow operation
Compatible with industrial fraction collection systems
✅ Important: A specialized process‑scale HPLC system is required for columns of this size
✅ Best Practice: Use proper sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain long‑term performance
Why Choose PFP (F5) Columns for Process‑Scale Work
Enhanced Selectivity for Complex Mixtures
Strong interaction with halogenated and fluorinated compounds
Improved selectivity vs traditional C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole interactions and hydrogen bonding
Greater flexibility for purification method development
100 Å Pore Structure
Suitable for small to moderately sized molecules
Consistent performance from analytical development to production scale
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and recovery
Ultra‑Low Backpressure (10 µm Particles)
Enables very high flow rates
Reduces strain on process‑scale systems
High Purity Silica
Reliable and reproducible chromatographic performance
Consistent purification results in production environments
Typical Applications
Process‑scale HPLC purification
Pilot‑scale and production compound isolation
Halogenated compound purification
Aromatic compound separations
Pharmaceutical manufacturing and scale‑up
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires process‑scale HPLC system capability
Designed for ultra high‑flow operation (50 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable