Catalog Number - 68134-10P-2

Cogent RP Cyano™ is a versatile reversed-phase UHPLC stationary phase designed for polar and neutral compound separations where reduced retention and rapid equilibration are desired. Manufactured with a cyanopropyl bonded phase on ultra-high purity silica and supplied without endcapping, this chemistry provides distinct selectivity compared to traditional alkyl phases. RP Cyano™ is commonly used as an alternative for USP L10 methods and offers shorter retention times than many conventional reversed-phase columns while maintaining excellent chromatographic performance.

68134-10P-2 is one of the most popular Cogent RP Cyano™ UHPLC columns, packed with 1.8 µm particles and a 100 Å pore size in a 2.1 mm ID format. The narrow-bore design reduces solvent consumption and is commonly selected for LC-MS applications. The sub-2 µm particle technology provides exceptional efficiency and peak capacity, while the column is specifically engineered for high-pressure UHPLC operation. Typical operating flow rates are approximately 0.2–0.4 mL/min. Because of the low flow rates required by 2.1 mm ID columns, standard HPLC systems must be capable of precise and reproducible low-flow operation if they are used with this column.

This column is particularly useful for polar and neutral compounds requiring reversed-phase retention with fast equilibration and efficient separations. Packed and shipped in reversed-phase solvents, it provides the selectivity of cyanopropyl chemistry combined with the speed and efficiency advantages of UHPLC technology.

Key Benefits

• RP Cyano™ stationary phase

• USP L10 equivalent chemistry

• Cyanopropyl bonded phase

• Ultra-high purity silica support

• Designed for UHPLC applications

• High-efficiency 1.8 µm particles

• Unique selectivity compared to C8 and C18 phases

• Shorter retention times for many analytes

• Rapid equilibration between runs

• Ideal for LC-MS methods

Typical Applications

• USP L10 methods

• UHPLC analysis

• LC-MS methods

• Polar compound analysis

• Neutral compound analysis

• Pharmaceutical analysis

• Method development

• Impurity profiling

• Fast reversed-phase separations

• Quality control testing

Specifications

• Product Type: UHPLC Column

• Stationary Phase: RP Cyano™

• USP Classification: L10

• Chromatography Mode: Reversed Phase

• Bonded Phase: Cyanopropyl

• Endcapping: Not Endcapped

• Particle Size: 1.8 µm

• Pore Size: 100 Å

• Column Dimensions: 2.1 mm ID x 50 mm

• Length: 50 mm

• Typical Flow Rate: 0.2–0.4 mL/min

• Brand: Cogent

Important Notes

• Designed specifically for UHPLC operation and high-pressure reversed-phase chromatography

• 1.8 µm particles generate substantially higher backpressure than conventional HPLC columns

• Maximum performance is achieved on UHPLC systems designed for sub-2 µm particle technology

• The 2.1 mm ID format is commonly used for LC-MS applications

• Standard HPLC systems must be capable of precise and reproducible operation at approximately 0.2–0.4 mL/min

• Packed and shipped in reversed-phase solvents

• View Cogent NP Cyano Columns packed in Normal Phase solvents for Normal Phase applications

• Samples should be filtered through a 0.2 µm syringe filter prior to injection

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