Catalog Number - 75018-15P-2

The 75018‑15P‑2 Cogent HPS C18™ HPLC Column is engineered for high‑resolution LC‑MS separations, delivering clean baseline performance, excellent peak shape, and consistent selectivity.

Built with monofunctional C18 bonding on proprietary high‑purity silica with full double end‑capping, this column minimizes secondary interactions and provides reliable performance for USP L1 methods and advanced LC‑MS workflows.

✅ Frequently used as a cost‑effective alternative to Inertsil™ C18 and Luna™ C18 columns

✅ One of the most popular LC‑MS column formats for resolution‑critical applications

150 mm Length – Maximum Resolution for LC‑MS Methods

• Highest resolving power in the 2.1 mm HPS column range

• Improves separation of closely eluting and trace‑level analytes

• Increases peak capacity for complex sample matrices

• Ideal for:

  • method validation

  • final method optimization

  • trace analysis workflows

✅ Selected when maximum resolution is required beyond 50 mm and 100 mm columns

2.1 mm ID – LC‑MS / Low‑Flow Optimization

• Optimized for low‑flow UHPLC and LC‑MS systems

• Enhances detector sensitivity via reduced solvent flow

Typical Flow Rate Range

• ~0.2–0.3 mL/min

✅ Requires systems capable of accurate and stable low‑flow delivery

⚠️ Ensure:

• Precision pump control

• Low‑volume detector flow cell compatibility

5 µm Particle – Reliable LC‑MS Performance

• Provides:

  • Balanced efficiency and durability

  • Lower backpressure vs smaller particles

  • Long operational lifetime

✅ Ideal for:

• LC‑MS systems without UHPLC pressure capability

• Method transfer between platforms

• Routine and validation workflows

120 Å Pore Size – Enhanced Versatility

• Larger than traditional 100 Å phases

• Improves performance with:

  • moderately larger molecules

  • complex analytes

✅ Provides expanded method flexibility and broader analyte compatibility

Why Choose HPS C18™ Columns

High‑Purity Silica Platform

• Reduces:

  • metal contamination

  • secondary interactions

• Improves:

  • peak symmetry

  • analytical reproducibility

Monofunctional C18 Bonding

• Provides:

  • predictable surface chemistry

  • consistent chromatographic behavior

✅ Ideal for reproducible analytical methods

LC‑MS Performance Advantage

• Clean baseline and low bleed characteristics

• Optimized for high‑sensitivity MS detection

✅ Suitable for trace‑level analysis and regulated workflows

Cost‑Performance Alternative

• Comparable performance to:

  • Inertsil™ C18

  • Luna™ C18

✅ Provides premium performance at competitive cost

Application Performance Advantages

• Suitable for:

  • Hydrophobic compounds

  • Neutral analytes

  • Long‑chain fatty acids

• Provides:

  • Strong retention vs C8 phases

  • Reliable separation performance across LC‑MS workflows

✅ Ideal for high‑resolution LC‑MS and analytical chromatography

System & Sample Considerations

• Designed for low‑flow LC‑MS systems (2.1 mm ID)

• Requires:

  • Stable and precise pump performance

  • Optimized detector configuration

Recommended sample preparation:

• 👉 Use 0.2 µm syringe filters for proper LC‑MS sample preparation before injection

✅ Helps:

• Prevent column clogging

• Maintain long‑term analytical performance

Typical Applications

• LC‑MS and LC‑MS/MS workflows

• USP L1 analytical methods

• Pharmaceutical QC and validation

• Stability‑indicating and trace analysis

• Method development and optimization

• Complex mixture separations

Important Usage Notes

• Designed for low‑flow LC‑MS systems (~0.2–0.3 mL/min)

• Requires precise pump control for optimal reproducibility

• Ideal for maximum‑resolution LC‑MS workflows

• Monitor system pressure relative to instrument capabilities