Syringe Filters, 4mm, Nylon, 0.45um Pore Size. Green Polypropylene, AQ Brand. 1000/CS.
Additional Info:
The 58045-N04-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput micro-volume membrane filters engineered for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm Nylon‑66 membrane, these filters deliver exceptional consistency, ultra-low adsorption, and extractable-free performance, ensuring accurate and reproducible analytical results—even with extremely limited sample volumes.
The 4 mm format is specifically designed for ultra-low volume filtration, minimizing hold-up volume and maximizing recovery from valuable or limited samples, making them ideal for LC‑MS workflows and precision analytical applications.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 210.3(b)(6) for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 20 µL of filtrate
✅ Preserves extremely valuable micro-volume samples
✅ Saves time and reduces risk of failed methods and costly investigations
👉 This creates a critical operational and compliance advantage for QC/QA laboratories and LC‑MS applications, where every microliter matters and reproducibility is essential.
Performance & Design
The 0.45 µm pore size is optimized for sample clarification and prefiltration, delivering fast flow rates with minimal resistance, even in compact filter formats.
Nylon‑66 membrane chemistry provides broad compatibility with aqueous and organic HPLC solvents, while maintaining ultra-low adsorption—even for charged analytes, ensuring accurate quantitation.
The 4 mm design significantly reduces hold-up volume, maximizing recovery from small or high-value samples, making it an optimal choice for micro-sample preparation and sensitive analytical workflows.
The green color coding allows rapid identification of 0.45 µm nylon filters, and each case includes a Certificate of Analysis for full traceability, compliance, and audit readiness.
Key Features
0.45 µm Nylon‑66 Membrane (Pharma Grade)
Ideal for clarification and prefiltration
High consistency for validated analytical methods
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 20 µL discard required
Ultra-Low Adsorption
Suitable for charged and sensitive analytes
Maximizes analyte recovery
Ultra-Low Volume Format (4 mm)
Minimizes hold-up volume
Maximizes recovery from micro-volume samples
Regulatory Compliance
Meets FDA CFR Title 21 requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
Broad Solvent Compatibility
Compatible with aqueous and organic HPLC solvents
Ideal for mixed solvent systems
Autoclavable & EO Sterilizable
121°C for 30 minutes or Ethylene Oxide
Color-Coded (Green)
Identifies 0.45 µm nylon filters
Bulk Packaging (1000/Case)
Reduces cost per analysis
Ideal for high-throughput and LC‑MS labs
Typical Applications
HPLC & UHPLC Sample Preparation – micro-volume sample clarification
LC‑MS Workflows – maximum recovery with minimal sample loss
Method Development – limited or high-value samples
Dissolution Testing – pharmaceutical QC applications
Regulated Laboratory Methods – validated, compliant workflows
High-Throughput Labs – consistent and efficient performance
Specifications
Filter Type: Syringe Filter (Pharma Grade)
Membrane Material: Nylon‑66
Pore Size: 0.45 µm
Diameter: 4 mm
Housing Material: Polypropylene (PP)
Color Code: Green (0.45 µm Nylon)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Aqueous and organic solvents
Extractables: None detectable (no flush required)
Initial Discard Volume: None (20 µL not required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21, USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Pack Size: 1000/Case
Brand: AQ™
Resources & Ordering Options
Order Nylon‑66 syringe filters, 0.45 µm, 4 mm – 100/pack quantity
Purchase Nylon‑66 syringe filters, 0.45 µm, 4 mm – 50/pack quantity