CUSTOM ITEM: Syringe Filters, 25mm, PTFE, 1.0um Pore Size. White Polypropylene, AQ Brand.
Additional Info:
The 58001-P25-K AQ™ Syringe Filters are pharmaceutical-grade membrane filters designed for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 1.0 µm PTFE (Polytetrafluoroethylene) membrane, these filters provide exceptional chemical resistance, high flow rates, and extractable-free performance, ensuring reliable and reproducible results for specialized applications.
The 1.0 µm pore size is optimized for coarse filtration and high particulate load reduction, making these filters ideal for pre-filtration prior to finer membranes or for heavily contaminated samples.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 210.3(b)(6) for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 200 µL of filtrate
✅ Preserves valuable samples
✅ Eliminates a common source of failed methods and investigations
👉 This ensures maximum efficiency and compliance, particularly in regulated or validated workflows.
Performance & Design
The 1.0 µm PTFE membrane is optimized for high-flow, coarse filtration, making it ideal for removal of large particulates prior to final filtration steps or for samples that would otherwise quickly clog finer membranes.
PTFE membrane chemistry provides superior chemical resistance, ensuring compatibility with organic solvents, strong acids, and bases, without degradation.
⚠️ Important: PTFE is hydrophobic and not recommended for 100% aqueous or buffer solutions, making it best suited for organic or mixed-phase solvent systems.
The white polypropylene housing is clearly marked with membrane type and pore size, minimizing identification errors in multi-filter workflows.
The 25 mm diameter supports high throughput and larger sample volumes, making this filter ideal for preparative or high-load applications.
Each package includes a Certificate of Analysis to support full regulatory traceability.
Key Features
1.0 µm PTFE Membrane (Custom Pharma Grade)
Ideal for coarse filtration and prefiltration
Handles high particulate loads
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 200 µL discard required
Superior Chemical Resistance
Compatible with organic solvents, acids, and bases
Will not degrade in harsh conditions
⚠️ Hydrophobic Membrane
Not suitable for 100% aqueous solutions
Designed for organic or mixed-phase systems
High Throughput Performance (25 mm)
Supports larger volumes
Reduces clogging in upstream filtration
Clear Identification Housing (White)
Printed membrane and pore size details
Minimizes user error
Low Extractables
Clean chromatographic baselines
Improves reproducibility
Regulatory Compliance
Meets FDA CFR Title 21 requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
Typical Applications
HPLC Sample Preparation – coarse prefiltration
Dissolution Testing – high particulate samples
Pre-Filtration Step – prior to 0.45 µm or 0.22 µm filtration
Organic Solvent Filtration – aggressive chemical systems
Environmental Samples – dirty or particulate-heavy matrices
Industrial & R&D Laboratories – specialized workflows
Specifications
Filter Type: Syringe Filter (Custom Order, Pharma Grade)
Membrane Material: PTFE (Polytetrafluoroethylene)
Pore Size: 1.0 µm
Diameter: 25 mm
Housing Material: Polypropylene (PP)
Color Code: White (custom PTFE configuration)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Organic solvents, acids, bases
Hydrophilicity: Hydrophobic (not for aqueous solutions)
Extractables: None detectable (no flush required)
Compliance: FDA CFR 21, USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Brand: AQ™
Order Type: Custom (non-cancelable / non-returnable)
Resources & Ordering
Contact Customer Service to request a formal quotation for AQ™ custom syringe filters
Learn more about AQ™ Custom Order manufacturing policies and requirements