Catalog Number - 58022-N25-K

The 58022-N25-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm Nylon‑66 membrane, these filters deliver exceptional consistency, ultra-low adsorption, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results in high-volume workflows.

The 0.22 µm pore size is designed for sterile filtration and fine particulate removal, protecting analytical systems and ensuring sample integrity in critical methods.

✅ Critical Compliance Advantage (No Flush Required)

These filters are validated and certified to meet stringent regulatory requirements, including:

• US FDA CFR Title 21, Part 210.3(b)(6) for minimum fiber release

• USP <788> for particulate matter in injectables

• USP requirements for “Sterile Water for Injection”

Because of this validated performance:

• ✅ No initial flushing is required

• ✅ No need to discard the first 200 µL of filtrate

• ✅ Preserves valuable samples and saves analyst time

• ✅ Eliminates a common source of failed methods and investigations

👉 This delivers a critical operational and compliance advantage, particularly for QC/QA laboratories and regulated environments, where efficiency, traceability, and method reliability are essential.

Performance & Design

The advanced 16-channel outlet design minimizes back pressure, allowing smooth filtration with reduced hand force, which improves ergonomics and consistency in high-throughput workflows.

Nylon‑66 membrane chemistry ensures broad compatibility with both aqueous and organic HPLC solvents, while maintaining ultra-low adsorption—even for charged analytes, supporting accurate quantitation.

The 25 mm format supports high sample throughput, while purple color coding provides immediate identification of 0.22 µm nylon filters.

Each case is supplied with a Certificate of Analysis, ensuring full compliance, traceability, and audit readiness.

Key Features

0.22 µm Nylon‑66 Membrane (Pharma Grade)

• Ideal for sterile filtration and fine particulate removal

• Ensures maximum sample clarity and system protection

✅ No Initial Flush Required (Validated)

• Extractable-free from first filtrate

• Eliminates sample waste and variability

Ultra-Low Adsorption

• Suitable for charged and sensitive analytes

• Maximizes analyte recovery

Advanced 16-Channel Outlet Design

• Reduces back pressure

• Requires less hand force

Regulatory Compliance

• Meets FDA CFR Title 21 requirements

• Complies with USP <788>

• Suitable for Sterile Water for Injection

Broad Solvent Compatibility

• Compatible with aqueous and organic solvents

• Ideal for mixed HPLC mobile phases

25 mm Diameter for High Throughput

• Handles larger sample volumes

• Improves productivity in high-volume labs

Autoclavable & EO Sterilizable

• 121°C for 30 minutes or Ethylene Oxide

Color-Coded (Purple)

• Identifies 0.22 µm nylon filters

Bulk Packaging (1000/Case)

• Reduces cost per test

• Ideal for high-throughput QC environments

Typical Applications

• HPLC & UHPLC Sample Preparation – fine particulate removal prior to injection

• Sterile Filtration – bacterial and contaminant removal

• Dissolution Testing – pharmaceutical QC and release workflows

• Regulated Laboratory Methods – validated, compliant processes

• Pharmaceutical Analysis – injectables and formulations

• High-Throughput QC Labs – consistent, efficient performance

Specifications

• Filter Type: Syringe Filter (Pharma Grade)

• Membrane Material: Nylon‑66

• Pore Size: 0.22 µm

• Diameter: 25 mm

• Housing Material: Polypropylene (PP)

• Color Code: Purple (0.22 µm Nylon)

• Connection Type: Luer Lock / Slip

• Chemical Compatibility: Aqueous and organic solvents

• Extractables: None detectable (no flush required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21, USP <788>

• Certification: Certificate of Analysis included

• Sterility: Non-sterile

• Pack Size: 1000/Case

• Brand: AQ™

Resources & Ordering Options

• Order Nylon‑66 syringe filters, 0.22 µm, 25 mm – 100/pack quantity

• Purchase Nylon‑66 syringe filters, 0.22 µm, 25 mm – 50/pack quantity