Catalog Number - 58022-P04-A

The 58022-P04-A AQ™ Syringe Filters are pharmaceutical-grade, ultra-low volume membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm PTFE (Polytetrafluoroethylene) membrane, these filters provide exceptional chemical resistance, sterile filtration capability, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results—even with extremely limited sample volumes.

PTFE membranes are the preferred choice for organic solvent systems, offering superior durability and compatibility with aggressive solvents, acids, and bases, making them ideal for demanding analytical and LC‑MS workflows.

✅ Critical Compliance Advantage (No Flush Required)

These filters are validated and certified to meet stringent regulatory requirements, including:

• US FDA CFR Title 21, Part 211.92 for minimum fiber release

• USP <788> for particulate matter in injectables

• USP requirements for “Sterile Water for Injection”

Because of this validated performance:

• ✅ No initial flushing is required

• ✅ No need to discard the first 20 µL of filtrate

• ✅ Preserves extremely valuable micro-volume samples

• ✅ Eliminates a common source of failed methods and investigations

👉 This provides a critical operational advantage for QC/QA and LC‑MS laboratories, where sample conservation and reproducibility are essential.

Performance & Design

The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum clarity and protection of analytical systems.

PTFE membrane chemistry provides maximum chemical compatibility, ensuring reliable performance in organic solvents, strong acids, and alkaline solutions, without degradation.

⚠️ Important: PTFE membranes are hydrophobic and not recommended for 100% aqueous or buffer solutions, making them best suited for organic or mixed-phase solvent systems requiring sterile filtration.

The 4 mm format minimizes hold-up volume, maximizing recovery from high-value, limited-volume samples, making these filters ideal for LC‑MS, method development, and precision analytical workflows.

The blue housing allows quick identification of 0.22 µm PTFE filters, and each pack includes a Certificate of Analysis for full traceability and compliance.

Key Features

0.22 µm PTFE Membrane (Pharma Grade)

• Ideal for sterile filtration and fine particulate removal

• Excellent chemical resistance

✅ No Initial Flush Required (Validated)

• Extractable-free from first filtrate

• No 20 µL discard required

Superior Chemical Resistance

• Compatible with solvents, acids, and bases

• Will not degrade under harsh conditions

⚠️ Hydrophobic Membrane

• Not suitable for 100% aqueous solutions

• Designed for organic or mixed-phase applications

Sterile Filtration Capability

• Suitable for critical pharmaceutical and analytical workflows

Ultra-Low Volume Format (4 mm)

• Minimizes hold-up volume

• Maximizes recovery from micro-volume samples

High Throughput Performance

• Fast filtration with minimal resistance

• Ideal for analytical workflows

Low Extractables

• Ensures clean chromatographic baselines

• Improves reproducibility

Regulatory Compliance

• Meets FDA CFR Title 21 (211.92) requirements

• Complies with USP <788>

• Suitable for Sterile Water for Injection

Color-Coded (Blue)

• Identifies 0.22 µm PTFE filters

Typical Applications

• HPLC & UHPLC Sample Preparation – micro-volume sterile filtration of organic solvents

• LC‑MS Workflows – maximum recovery with minimal loss

• Pharmaceutical Analysis – dissolution and QC workflows

• Organic & Chemical Analysis – aggressive solvent systems

• Method Development – limited or high-value samples

• Regulated Laboratory Methods – validated, compliant processes

Specifications

• Filter Type: Syringe Filter (Pharma Grade)

• Membrane Material: PTFE (Polytetrafluoroethylene)

• Pore Size: 0.22 µm

• Diameter: 4 mm

• Housing Material: Polypropylene (PP)

• Color Code: Blue (0.22 µm PTFE)

• Connection Type: Luer Lock / Slip

• Chemical Compatibility: Organic solvents, acids, bases

• Hydrophilicity: Hydrophobic (not for aqueous solutions)

• Extractables: None detectable (no flush required)

• Initial Discard Volume: None (20 µL not required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21 (211.92), USP <788>

• Certification: Certificate of Analysis included

• Sterility: Non-sterile

• Pack Size: 50/PK

• Brand: AQ™

Resources & Ordering Options

• Purchase PTFE syringe filters, 0.22 µm, 4 mm – 100/pack quantity

• Order PTFE syringe filters, 0.22 µm, 4 mm – 1000/case quantity