Catalog Number - 58022-R25-K

The 58022-R25-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput regenerated cellulose (RC) membrane filters designed for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm regenerated cellulose membrane, these filters provide low extractables, high analyte recovery, and consistent chromatographic performance.

Regenerated cellulose membranes offer very low protein binding and minimal hold-up volume, making them ideal for protein solutions, buffers, and cell culture media, especially when maximum recovery is critical.

✅ Critical Compliance Advantage (No Flush Required)

Validated to meet key regulatory standards:

• US FDA CFR Title 21, Part 211.92 – minimum fiber release

• USP <788> – particulate matter in injectables

• USP “Sterile Water for Injection”

Benefits:

• ✅ No initial flushing required

• ✅ No 200 µL discard required

• ✅ Improves sample recovery and efficiency

• ✅ Reduces risk of failed methods

Performance & Design

The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, ensuring maximum protection of analytical systems.

The RC membrane provides low adsorption and excellent recovery, making it ideal for biological and aqueous samples.

The 25 mm format supports larger sample volumes, while 1000/case packaging is ideal for high-throughput laboratories and production workflows.

Not recommended for use with strong acids or bases.

The grey housing allows easy identification of 0.22 µm RC filters, and each case includes a Certificate of Analysis.

Key Features

0.22 µm Regenerated Cellulose Membrane (Pharma Grade)

• Very low protein binding

• Ideal for biological and aqueous samples

✅ No Initial Flush Required (Validated)

• No 200 µL discard required

Low Hold-Up Volume

• Maximizes analyte recovery

Sterile Filtration Capability

• Removes fine particulates and microorganisms

High Throughput (25 mm)

• Handles larger sample volumes

Bulk Packaging (1000/Case)

• Reduces cost per analysis

• Ideal for high-volume workflows

Low Extractables

• Clean analytical results

Biological Compatibility

• Suitable for proteins, buffers, and media

Regulatory Compliance

• FDA CFR 21 (211.92), USP <788>

Color-Coded (Grey)

• Identifies 0.22 µm RC filters

Typical Applications

• HPLC & UHPLC Sample Preparation – sterile filtration

• Protein & Biomolecule Samples – maximum recovery

• Cell Culture Media & Buffers

• Dissolution Testing – pharmaceutical QC

• High-Throughput Laboratories – consistent workflows

Specifications

• Membrane Material: Regenerated Cellulose (RC)

• Pore Size: 0.22 µm

• Diameter: 25 mm

• Housing: Polypropylene (PP)

• Color Code: Grey

• Protein Binding: Very Low

• Hydrophilicity: Hydrophilic

• Extractables: None detectable (no flush required)

• Chemical Compatibility: Aqueous solutions (avoid strong acids/bases)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21, USP <788>

• Pack Size: 1000/Case

• Brand: AQ™

Resources & Ordering Options

• Purchase regenerated cellulose syringe filters, 0.22 µm, 25 mm – 50/pack quantity

• Order regenerated cellulose syringe filters, 0.22 µm, 25 mm – 100/pack quantity