Catalog Number - 58045-CA04-C

The 58045-CA04-C AQ™ Syringe Filters are pharmaceutical-grade, ultra-low volume membrane filters designed for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm Cellulose Acetate (CA) membrane, these filters provide consistent performance, low extractables, and reliable chromatographic results, even with very small sample volumes.

Cellulose Acetate membranes are naturally hydrophilic and surfactant-free, eliminating extractable contaminants common in many hydrophilic filters. With very low protein binding, they are ideal for biological and aqueous samples where maximum recovery is critical.

✅ Critical Compliance Advantage (No Flush Required)

Validated to meet key regulatory standards:

• US FDA CFR Title 21, Part 211.92 – minimum fiber release

• USP <788> – particulate matter in injectables

• USP “Sterile Water for Injection”

Benefits:

• ✅ No initial flushing required

• ✅ No 20 µL discard required

• ✅ Maximizes recovery of micro-volume samples

• ✅ Reduces risk of failed methods

Performance & Design

The 0.45 µm pore size is optimized for sample clarification and prefiltration, delivering fast flow rates and reduced clogging.

The 4 mm format minimizes hold-up volume, making it ideal for micro-volume and high-value samples, including LC‑MS workflows and method development.

CA membranes perform best in aqueous and biological applications, where low protein binding and clean baselines are essential.

The orange housing enables quick identification, and each pack includes a Certificate of Analysis.

Key Features

0.45 µm Cellulose Acetate Membrane (Pharma Grade)

• Ideal for aqueous and biological samples

• Surfactant-free, low extractables

✅ No Initial Flush Required (Validated)

• No 20 µL discard required

Low Protein Binding

• Maximizes analyte recovery

Hydrophilic Membrane

• No pre-wetting required

Ultra-Low Volume Format (4 mm)

• Minimizes hold-up volume

• Maximizes recovery

Regulatory Compliance

• FDA CFR 21 (211.92), USP <788>

Color-Coded (Orange)

• Identifies CA filters

Typical Applications

• HPLC & UHPLC Sample Preparation – micro-volume aqueous filtration

• LC‑MS Workflows – high-value sample recovery

• Biological Samples – protein / biomolecule filtration

• Dissolution Testing – pharmaceutical QC

• Method Development – limited sample volumes

Specifications

• Membrane Material: Cellulose Acetate (CA)

• Pore Size: 0.45 µm

• Diameter: 4 mm

• Housing: Polypropylene (PP)

• Color Code: Orange

• Protein Binding: Low

• Hydrophilicity: Hydrophilic

• Extractables: None detectable (no flush required)

• Initial Discard Volume: None (20 µL not required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21, USP <788>

• Pack Size: 100/PK

• Brand: AQ™

Resources & Ordering Options

• Purchase Cellulose Acetate syringe filters, 0.45 µm, 4 mm – 50/pack quantity

• Order Cellulose Acetate syringe filters, 0.45 µm, 4 mm – 1000/case quantity

, Click HERE for 1000 in a package quantity or Click HERE for 50 in a package quantity.