Syringe Filters, 4mm, PTFE, 0.45um Pore Size. Yellow Polypropylene, AQ Brand. 1000/CS.
Additional Info:
The 58045-P04-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput micro-volume membrane filters engineered for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm PTFE (Polytetrafluoroethylene) membrane, these filters provide exceptional chemical resistance, fast flow rates, and extractable-free filtration, ensuring consistent, reliable analytical results—even with extremely limited sample volumes.
PTFE membranes are the preferred choice for organic solvent systems, offering superior durability and compatibility with aggressive solvents, acids, and bases, making them ideal for demanding analytical and LC‑MS workflows.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 211.92 for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 20 µL of filtrate
✅ Preserves extremely valuable micro-volume samples
✅ Eliminates a common source of failed methods and costly investigations
👉 This provides a critical operational advantage for QC/QA and LC‑MS laboratories, where every microliter matters and reproducibility is essential.
Performance & Design
The 0.45 µm pore size is optimized for sample clarification and prefiltration, delivering high flow rates and reduced clogging, even in compact filter formats.
PTFE membrane chemistry ensures maximum chemical compatibility, allowing reliable filtration of organic solvents, strong acids, and alkaline solutions, without degradation.
⚠️ Important: PTFE membranes are hydrophobic and not recommended for 100% aqueous or buffer solutions, making them best suited for organic or mixed solvent workflows.
The 4 mm design minimizes hold-up volume, maximizing recovery from limited or high-value samples, making these filters ideal for LC‑MS analysis, method development, and micro-volume workflows.
The bulk 1000/case packaging supports high-throughput laboratories and production-scale environments.
The yellow housing allows quick identification of 0.45 µm PTFE filters, and each case includes a Certificate of Analysis for full traceability and compliance.
Key Features
0.45 µm PTFE Membrane (Pharma Grade)
Ideal for organic solvent filtration
High chemical resistance and durability
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 20 µL discard required
Superior Chemical Resistance
Compatible with solvents, acids, and bases
Will not degrade under harsh conditions
⚠️ Hydrophobic Membrane
Not suitable for 100% aqueous solutions
Designed for organic or mixed-phase applications
Ultra-Low Volume Format (4 mm)
Minimizes hold-up volume
Maximizes recovery from micro-volume samples
High Throughput Performance
Fast filtration with minimal resistance
Suitable for high-volume workflows
Low Extractables
Ensures clean chromatographic baselines
Improves reproducibility
Regulatory Compliance
Meets FDA CFR Title 21 (211.92) requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
Color-Coded (Yellow)
Identifies 0.45 µm PTFE filters
Bulk Packaging (1000/Case)
Reduces cost per analysis
Ideal for high-throughput labs
Typical Applications
HPLC & UHPLC Sample Preparation – micro-volume organic solvent filtration
LC‑MS Workflows – maximum recovery with minimal loss
Pharmaceutical Analysis – dissolution and QC workflows
Organic & Chemical Analysis – aggressive solvent systems
Method Development – high-value or limited samples
High-Throughput Laboratories – consistent and efficient processing
Specifications
Filter Type: Syringe Filter (Pharma Grade)
Membrane Material: PTFE (Polytetrafluoroethylene)
Pore Size: 0.45 µm
Diameter: 4 mm
Housing Material: Polypropylene (PP)
Color Code: Yellow (0.45 µm PTFE)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Organic solvents, acids, bases
Hydrophilicity: Hydrophobic (not for aqueous solutions)
Extractables: None detectable (no flush required)
Initial Discard Volume: None (20 µL not required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21 (211.92), USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Pack Size: 1000/Case
Brand: AQ™
Resources & Ordering Options
Order PTFE syringe filters, 0.45 µm, 4 mm – 100/pack quantity
Purchase PTFE syringe filters, 0.45 µm, 4 mm – 50/pack quantity