Syringe Filters, 25mm, PTFE, 0.45um Pore Size. Yellow Polypropylene, AQ Brand. 1000/CS.
Additional Info:
The 58045-P25-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput membrane filters engineered for HPLC sample preparation and dissolution testing in regulated laboratory environments. Featuring a 0.45 µm PTFE (Polytetrafluoroethylene) membrane, these filters deliver exceptional chemical resistance, high flow rates, and extractable-free performance, ensuring consistent, reliable chromatographic results in high-volume workflows.
PTFE membranes are ideal for organic solvent applications, offering unmatched chemical durability and resistance to aggressive solvents, acids, and bases, making them the preferred choice for demanding analytical and industrial workflows.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 211.92 for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 200 µL of filtrate
✅ Preserves valuable samples
✅ Eliminates a common source of failed methods and costly investigations
👉 This provides a major operational and compliance advantage for QC/QA laboratories, particularly in regulated environments using costly or high-value solvent systems.
Performance & Design
The 0.45 µm pore size is optimized for sample clarification and prefiltration, delivering high flow rates and reduced clogging, ideal for routine and high-throughput workflows.
PTFE membrane chemistry provides maximum chemical compatibility and durability, ensuring stable performance in organic solvents, strong acids, and alkaline conditions, without degradation.
⚠️ Important: PTFE is hydrophobic and not recommended for 100% aqueous or buffer solutions, making it best suited for organic or mixed solvent systems.
The advanced 16-channel outlet design minimizes back pressure, enabling smooth filtration with reduced hand force, improving ergonomics and user consistency in repetitive workflows.
The 25 mm format supports larger sample volumes and high-throughput applications, while the bulk 1000/case packaging is ideal for production-scale and high-volume laboratory environments.
The yellow housing allows immediate identification of 0.45 µm PTFE filters, and each case includes a Certificate of Analysis for full traceability and compliance.
Key Features
0.45 µm PTFE Membrane (Pharma Grade)
Ideal for organic solvent filtration
High chemical resistance and durability
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 200 µL discard required
Superior Chemical Resistance
Compatible with strong solvents, acids, and bases
Will not degrade under harsh conditions
⚠️ Hydrophobic Membrane
Not suitable for 100% aqueous solutions
Designed for organic or mixed-phase systems
High Throughput Performance (25 mm)
Handles larger sample volumes
Ideal for routine and high-volume workflows
Advanced 16-Channel Outlet Design
Reduces back pressure
Requires less hand force
Low Extractables
Ensures clean chromatographic baselines
Improves reproducibility
Regulatory Compliance
Meets FDA CFR 21 (211.92) requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
Color-Coded (Yellow)
Identifies 0.45 µm PTFE filters
Bulk Packaging (1000/Case)
Reduces cost per analysis
Ideal for high-throughput QC laboratories
Typical Applications
HPLC & UHPLC Sample Preparation – organic solvent filtration
Pharmaceutical Analysis – dissolution and QC testing
Chemical & Organic Analysis – aggressive solvent systems
Environmental Testing – non-aqueous samples
Industrial Laboratory Applications – harsh chemical workflows
High-Throughput Labs – consistent and efficient performance
Specifications
Filter Type: Syringe Filter (Pharma Grade)
Membrane Material: PTFE (Polytetrafluoroethylene)
Pore Size: 0.45 µm
Diameter: 25 mm
Housing Material: Polypropylene (PP)
Color Code: Yellow (0.45 µm PTFE)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Organic solvents, acids, bases
Hydrophilicity: Hydrophobic (not for aqueous solutions)
Extractables: None detectable (no flush required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21 (211.92), USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Pack Size: 1000/Case
Brand: AQ™
Resources & Ordering Options