Catalog Number - 58846-03

58846-03 ARE‑Applied Research Mobile Phase Inlet Filter is a high‑performance, biocompatible solvent filtration device engineered for HPLC, UHPLC, and LC‑MS mobile phase delivery systems where maximum solvent utilization, high flow rates, and system protection are essential.

This filter utilizes an advanced “Last Drop” flat‑profile design, allowing users to draw nearly all available solvent from reservoir bottles—making it especially valuable for long runs, high‑throughput laboratories, and expensive mobile phases.

Constructed with a 2.5 µm PTFE filter element and an inert PEEK / PTFE wetted flow path, this design provides high chemical compatibility, low extractables, and biocompatibility for sensitive analytical workflows.

“Last Drop” Design – Maximum Solvent Recovery

• Wide 22 mm flat filter geometry

• Rests at the lowest point in the bottle

• Draws solvent to near‑dry conditions

• Minimizes waste and avoids run interruptions

✅ Ideal for overnight runs, long sequences, and high‑value solvents

✅ Improves efficiency and solvent cost control

2.5 µm PTFE Element – Biocompatible Filtration

• Removes particles ≥ 2.5 µm

• Protects:

  • Pump seals and check valves

  • Injection systems

  • HPLC columns and detectors

• PTFE filter media provides:

  • Broad chemical compatibility

  • Biocompatibility for sensitive workflows

  • Low adsorption and extractables

✅ Ideal for LC‑MS, pharmaceutical, and bioanalytical applications

Visual Inspection Advantage – White Filter Element

• White PTFE surface enhances visibility of trapped particles

• Allows quick inspection of contamination buildup

• Helps determine when replacement is needed

✅ Supports proactive maintenance and consistent flow performance

PEEK / PTFE Flow Path – High Purity Performance

• Wetted components made from:

  • PEEK (polyether ether ketone)

  • PTFE (inert fluoropolymer)

• Ensures:

  • Chemical inertness

  • Minimal leachables

  • Stable solvent compatibility

✅ Suitable for high‑purity chromatography workflows

1/8" Connector with ETFE Ferrule – High‑Flow Integration

• Integrated 1/8" tubing connector

• Includes ETFE ferrule for secure sealing

• Designed for non‑flanged low‑pressure tubing

• Leak‑free connection without additional fittings

✅ Ideal for higher flow rate systems and larger tubing configurations

Performance Advantages – Modern HPLC Best Practices

Compared to conventional inlet filters:

• Maximizes usable solvent volume

• Reduces risk of air entering pump systems

• Improves flow stability at low solvent levels

• Supports continuous, unattended operation

✅ Aligns with modern chromatography system protection strategies

System Compatibility & Use

Designed for use with:

• HPLC / UHPLC mobile phase systems

• LC‑MS solvent delivery setups

• Low‑pressure tubing systems (1/8")

• Standard mobile phase reservoir bottles

✅ Installs directly into mobile phase bottles for inline solvent filtration

Typical Applications

• HPLC mobile phase filtration

• LC‑MS solvent protection

• Biocompatible analytical workflows

• High‑throughput laboratories

• Long‑duration or unattended runs

• Integrated into original equipment manufacturer (OEM) product designs

Important Usage Notes

• Designed for low‑pressure systems only

• Ensure proper tubing insertion with ferrule

• Inspect filter element regularly for buildup

• Replace element when flow resistance increases