Catalog Number - 58846-04

58846-04 ARE‑Applied Research Mobile Phase Inlet Filter is a high‑performance, biocompatible solvent filtration device designed for HPLC, UHPLC, and LC‑MS mobile phase delivery systems, providing maximum solvent recovery, high flow capacity, and reliable system protection.

This version features a refined “Last Drop” bell‑shaped flat profile, which enhances surface contact with the solvent and improves “bottom draw” performance—allowing nearly complete use of mobile phase in reservoir bottles.

Manufactured with a 2.5 µm PTFE filter element and an inert PEEK / PTFE wetted flow path, this filter offers excellent chemical compatibility, low extractables, and suitability for sensitive analytical and biocompatible workflows.

Advanced “Last Drop” Bell Design – Maximum Solvent Utilization

• 22 mm wide, bell‑shaped flat geometry

• Optimized contact with bottle bottom for better solvent access

• Draws solvent to near‑empty conditions

• Reduces waste and prevents premature system shutdown

✅ Ideal for long sequences, overnight runs, and high‑value solvents

✅ Improves consistency and efficiency in analytical workflows

2.5 µm PTFE Element – Biocompatible Filtration

• Removes particles ≥ 2.5 µm

• Protects:

  • Pump seals and check valves

  • Injector components

  • Columns and detectors

• PTFE media provides:

  • Broad chemical compatibility

  • Biocompatibility for sensitive workflows

  • Low adsorption and extractables

✅ Ideal for LC‑MS, pharmaceutical, and bioanalytical applications

Visual Inspection Advantage – White Filter Element

• White PTFE surface enhances visibility of trapped particles

• Allows rapid inspection for contamination buildup

• Aids in determining when maintenance or replacement is needed

✅ Supports proactive maintenance and stable system performance

PEEK / PTFE Flow Path – High Purity Performance

• Wetted components made from:

  • PEEK (polyether ether ketone)

  • PTFE (inert fluoropolymer)

• Ensures:

  • Chemical inertness

  • Minimal leachables

  • Consistent solvent compatibility

✅ Suitable for high‑purity chromatography and LC‑MS workflows

Tripod Connector – Universal, Tool‑Free Connection

• All‑PEEK tripod tubing connector

• Accepts:

  • 1/16" OD tubing

  • 1/8" OD tubing

• No ferrules or nuts required

• Simple push‑fit installation and removal

• Designed for flexible system configurations

✅ Enables fast setup and reliable connections across multiple tubing sizes

Performance Advantages – Modern Chromatography Practices

Compared to traditional inlet filters:

• Maximizes usable solvent volume

• Reduces risk of air entering pump systems

• Improves flow stability at low solvent levels

• Supports continuous, unattended operation

Bell‑style “Last Drop” filters are especially valued for:

• Improved bottom contact and solvent draw efficiency

• Higher usable fraction of mobile phase

• Reduced need for operator intervention

✅ Aligns with best practices in HPLC system protection and solvent management

System Compatibility & Use

Designed for use with:

• HPLC / UHPLC mobile phase systems

• LC‑MS solvent delivery setups

• Low‑pressure tubing configurations (1/16" and 1/8")

• Standard mobile phase reservoir bottles

✅ Installs directly into mobile phase bottles for inline filtration

Typical Applications

• HPLC mobile phase filtration

• LC‑MS solvent protection

• Biocompatible analytical workflows

• High‑throughput laboratories

• Long‑duration and unattended runs

• Integrated into original equipment manufacturer (OEM) product designs

Important Usage Notes

• Designed for low‑pressure systems only

• Ensure tubing is properly seated for secure connection

• Inspect filter element regularly for particulate buildup

• Replace when flow resistance increases