HPLC Column, Nova Similars C18, 4um, 2.1mm ID x 50mm Length. Cogent Brand. 1 EA.
Additional Information:
Nova Similars C18™ is a traditional reversed-phase HPLC stationary phase manufactured on high-purity Type-B spherical silica with a fully endcapped octadecyl (C18) bonded phase. Designed as a cost-effective alternative to Waters™ Nova-Pak® columns, it offers comparable chromatographic behavior for USP L1 methods while providing the strong hydrophobic retention, reproducibility, and broad applicability expected from a conventional C18 stationary phase.
64418-05P-2 is a 50 mm x 2.1 mm ID narrow-bore analytical column packed with 4 µm Nova Similars C18 particles. The short 50 mm length is optimized for fast analyses and reduced solvent consumption, while the 2.1 mm ID format is especially well suited for LC-MS applications. The 4 µm particle size provides improved efficiency and somewhat sharper peaks than comparable 5 µm columns while maintaining moderate operating pressure. Typical flow rates are approximately 0.2–0.3 mL/min and require a system capable of precise low-flow delivery with low-volume flow cells and plumbing.
This USP L1 column is ideal for hydrophobic and neutral compounds requiring strong reversed-phase retention. Its narrow-bore format, low-flow operation, and rapid analysis capability make it a popular choice for LC-MS methods, pharmaceutical analysis, long-chain fatty acid separations, and high-sensitivity analytical workflows.
Key Benefits
Type-B spherical silica stationary phase
Suitable alternative for USP L1 methods
Comparable selectivity to Waters™ Nova-Pak® C18 columns
Narrow-bore format ideal for LC-MS applications
Fast analysis with 50 mm column length
Higher efficiency than comparable 5 µm columns
Reduced solvent consumption
End-capped C18 bonded phase
Typical Applications
USP L1 methods
LC-MS analysis
Reversed-phase HPLC
Pharmaceutical analysis
Long-chain fatty acid analysis
Quality control testing
Fast analytical separations
Method transfer and validation
Specifications
Product Type: HPLC Column
Stationary Phase: Nova Similars C18
USP Classification: L1
Particle Size: 4 µm
Particle Type: Type-B Spherical Silica
Bonded Phase: C18 (Octadecyl)
Endcapped: Yes
Column Dimensions: 2.1 mm ID x 50 mm
Length: 50 mm
Recommended Flow Rate: 0.2–0.3 mL/min
Brand: Cogent
Important Notes
Designed for reversed-phase chromatography
Narrow-bore format optimized for LC-MS applications
Requires an HPLC or LC-MS system capable of reliable low-flow operation
Higher efficiency than comparable 5 µm columns
Reduced solvent consumption compared to 4.6 mm ID columns
Excellent alternative for many USP L1 methods
Ideal for high-throughput LC-MS workflows