Catalog Number - 67085-25P

Cogent IEX SAX is a strong anion exchange (SAX) HPLC stationary phase manufactured using high-purity silica and quaternary amine functional groups that maintain a permanent positive charge across a wide pH range. This strong anion exchange mechanism provides reliable retention and separation of negatively charged analytes, making the column suitable for ion exchange chromatography methods involving inorganic anions, organic acids, biomolecules, and other ionic compounds. The stationary phase is an excellent alternative for USP L9 methods and applications requiring robust anion exchange selectivity.

67085-25P is a 250 mm x 4.6 mm ID analytical column packed with 10 µm SAX particles with a 100 Å pore size. The extended 250 mm length provides increased theoretical plate counts and maximum resolving power for complex ion exchange separations, impurity profiling, purification studies, and challenging analytical applications requiring enhanced separation of closely related anionic compounds. The 10 µm particle size provides low backpressure and supports higher flow rates than smaller particle packings. Typical operating flow rates are approximately 1.0–3.0 mL/min on conventional HPLC systems.

This USP L9 column is particularly useful for the separation and purification of negatively charged compounds, including organic acids, inorganic anions, nucleotides, and other ionic species. The combination of strong anion exchange functionality, high capacity, and extended column length makes it ideal for applications where maximum resolution and chromatographic selectivity are required.

Key Benefits

• Strong anion exchange (SAX) stationary phase

• Quaternary amine functional groups

• Permanent positive surface charge

• Suitable alternative for USP L9 methods

• 10 µm particles for lower backpressure

• Supports higher flow rates

• Maximum resolving power from 250 mm column length

• High-purity silica support

Typical Applications

• USP L9 methods

• Ion exchange chromatography

• Organic acid analysis

• Inorganic anion separations

• Biomolecule analysis

• Impurity profiling

• Purification studies

• Quality control testing

Specifications

• Product Type: HPLC Column

• Stationary Phase: IEX SAX

• USP Classification: L9

• Chromatography Mode: Strong Anion Exchange

• Functional Group: Quaternary Amine

• Particle Size: 10 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 250 mm

• Length: 250 mm

• Recommended Flow Rate: 1.0–3.0 mL/min

• Brand: Cogent

Important Notes

• Designed for ion exchange chromatography

• Retains negatively charged analytes

• Quaternary amine groups remain charged across a broad pH range

• Longer column length provides maximum chromatographic resolution

• Lower backpressure compared to smaller particle columns

• Supports higher flow rates for routine and preparative methods

• Excellent alternative for many USP L9 methods

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