Catalog Number - 67586-10P

Cogent IEX SCX is a strong cation exchange (SCX) HPLC stationary phase manufactured using high-purity silica and sulfonic acid functional groups that maintain a permanent negative charge across a wide pH range. This strong cation exchange mechanism provides reliable retention and separation of positively charged analytes, making the column suitable for ion exchange chromatography methods involving basic compounds, amines, peptides, pharmaceuticals, and other cationic species. The stationary phase is an excellent alternative for USP L9 methods and applications requiring robust cation exchange selectivity.

67586-10P is a 100 mm x 4.6 mm ID analytical column packed with 5 µm SCX particles with a 100 Å pore size. The 100 mm length provides an excellent balance between chromatographic resolution and analysis time, while the 5 µm particle size delivers improved chromatographic efficiency, sharper peak shapes, and greater resolving power than larger particle packings. Typical operating flow rates are approximately 1.0–2.0 mL/min, making this column well suited for conventional HPLC systems and routine ion exchange applications.

This USP L9 column is particularly useful for the separation and purification of positively charged compounds, including basic pharmaceuticals, amines, peptides, alkaloids, and other ionic species. The combination of strong cation exchange functionality, high efficiency, and excellent reproducibility makes it ideal for routine analytical testing, method development, quality control laboratories, and demanding ion exchange applications requiring enhanced chromatographic performance.

Key Benefits

• Strong cation exchange (SCX) stationary phase

• Sulfonic acid functional groups

• Permanent negative surface charge

• Suitable alternative for USP L9 methods

• 5 µm particles for improved efficiency and resolution

• Balanced resolution and analysis time

• High chromatographic performance

• High-purity silica support

Typical Applications

• USP L9 methods

• Ion exchange chromatography

• Basic compound analysis

• Pharmaceutical analysis

• Amine separations

• Peptide analysis

• Method development

• Quality control testing

Specifications

• Product Type: HPLC Column

• Stationary Phase: IEX SCX

• USP Classification: L9

• Chromatography Mode: Strong Cation Exchange

• Functional Group: Sulfonic Acid

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for ion exchange chromatography

• Retains positively charged analytes

• Sulfonic acid groups remain charged across a broad pH range

• 100 mm length balances resolution and run time

• Higher efficiency than comparable 10 µm ion exchange columns

• Compatible with conventional HPLC systems

• Excellent alternative for many USP L9 methods

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