Catalog Number - 67586-15P

Cogent IEX SCX is a strong cation exchange (SCX) HPLC stationary phase manufactured using high-purity silica and sulfonic acid functional groups that maintain a permanent negative charge across a wide pH range. This strong cation exchange mechanism provides reliable retention and separation of positively charged analytes, making the column suitable for ion exchange chromatography methods involving basic compounds, amines, peptides, pharmaceuticals, and other cationic species. The stationary phase is an excellent alternative for USP L9 methods and applications requiring robust cation exchange selectivity.

67586-15P is a 150 mm x 4.6 mm ID analytical column packed with 5 µm SCX particles with a 100 Å pore size. The 150 mm length provides increased resolving power for more demanding ion exchange separations while maintaining excellent chromatographic efficiency. The 5 µm particle size delivers higher plate counts, sharper peaks, and improved chromatographic performance compared to larger particle packings. Typical operating flow rates are approximately 1.0–2.0 mL/min, making this column well suited for conventional HPLC systems and advanced ion exchange methods requiring enhanced resolution.

This USP L9 column is particularly useful for the separation and purification of positively charged compounds, including basic pharmaceuticals, amines, peptides, alkaloids, and other ionic species. The combination of strong cation exchange functionality, high efficiency, and increased column length makes it ideal for method development, quality control testing, impurity profiling, and complex ion exchange separations requiring greater chromatographic resolution.

Key Benefits

• Strong cation exchange (SCX) stationary phase

• Sulfonic acid functional groups

• Permanent negative surface charge

• Suitable alternative for USP L9 methods

• 5 µm particles for improved efficiency and resolution

• Increased resolving power from 150 mm column length

• High chromatographic performance

• High-purity silica support

Typical Applications

• USP L9 methods

• Ion exchange chromatography

• Basic compound analysis

• Pharmaceutical analysis

• Amine separations

• Peptide analysis

• Method development

• Impurity profiling

Specifications

• Product Type: HPLC Column

• Stationary Phase: IEX SCX

• USP Classification: L9

• Chromatography Mode: Strong Cation Exchange

• Functional Group: Sulfonic Acid

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 150 mm

• Length: 150 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for ion exchange chromatography

• Retains positively charged analytes

• Sulfonic acid groups remain charged across a broad pH range

• Increased resolving power for complex separations

• Higher efficiency than comparable 10 µm ion exchange columns

• Compatible with conventional HPLC systems

• Excellent alternative for many USP L9 methods

• One of the most popular Cogent SCX column configurations

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