Catalog Number - 67586-15P-2

Cogent IEX SCX is a strong cation exchange (SCX) HPLC stationary phase manufactured using high-purity silica and sulfonic acid functional groups that maintain a permanent negative charge across a wide pH range. This strong cation exchange mechanism provides reliable retention and separation of positively charged analytes, making the column suitable for ion exchange chromatography methods involving basic compounds, amines, peptides, pharmaceuticals, and other cationic species. The stationary phase is an excellent alternative for USP L9 methods and applications requiring robust cation exchange selectivity.

67586-15P-2 is a 150 mm x 2.1 mm ID narrow-bore analytical column packed with 5 µm SCX particles with a 100 Å pore size. The 150 mm length provides increased resolving power for more demanding ion exchange separations, while the 2.1 mm ID format minimizes solvent consumption and is well suited for LC-MS compatible ion exchange workflows requiring low flow rates. The 5 µm particle size delivers higher plate counts, sharper peaks, and improved chromatographic performance compared to larger particle packings. Typical operating flow rates are approximately 0.2–0.3 mL/min and require an HPLC or LC-MS system capable of reliable low-flow operation with low-volume plumbing and flow cells.

This USP L9 column is particularly useful for the separation and purification of positively charged compounds, including basic pharmaceuticals, amines, peptides, alkaloids, and other ionic species. The combination of strong cation exchange functionality, narrow-bore design, high-efficiency 5 µm particles, and increased column length makes it ideal for high-sensitivity analytical methods, method development, impurity profiling, and complex ion exchange separations requiring enhanced chromatographic resolution.

Key Benefits

• Strong cation exchange (SCX) stationary phase

• Sulfonic acid functional groups

• Permanent negative surface charge

• Suitable alternative for USP L9 methods

• 5 µm particles for improved efficiency and resolution

• Narrow-bore format minimizes solvent consumption

• Increased resolving power from 150 mm column length

• High-purity silica support

Typical Applications

• USP L9 methods

• Ion exchange chromatography

• Basic compound analysis

• Pharmaceutical analysis

• Amine separations

• Peptide analysis

• LC-MS compatible workflows

• Impurity profiling

Specifications

• Product Type: HPLC Column

• Stationary Phase: IEX SCX

• USP Classification: L9

• Chromatography Mode: Strong Cation Exchange

• Functional Group: Sulfonic Acid

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 2.1 mm ID x 150 mm

• Length: 150 mm

• Recommended Flow Rate: 0.2–0.3 mL/min

• Brand: Cogent

Important Notes

• Designed for ion exchange chromatography

• Retains positively charged analytes

• Sulfonic acid groups remain charged across a broad pH range

• Requires an HPLC or LC-MS system capable of reliable low-flow operation

• Increased resolving power for complex separations

• Higher efficiency than comparable 10 µm ion exchange columns

• Reduced solvent consumption compared to 4.6 mm ID columns

• Excellent alternative for many USP L9 methods

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