Catalog Number - 68018-PG2-3

The 68018‑PG2‑3 Cogent RP C18 Wide Pore Guard Column Cartridges are designed to extend the life of analytical HPLC columns, providing protection from particulates, strongly retained compounds, and sample matrix contamination in routine and advanced workflows.

Packed with 10 µm Cogent RP C18™ Wide Pore stationary phase (300 Å) and manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, these cartridges are fully double end‑capped to provide:

• Reduced silanol activity

• Improved peak shape for proteins, peptides, and large polar analytes

• Consistent and reproducible chromatographic protection

Each cartridge is constructed in a stainless steel body with stainless steel frits, secured with PEEK frit caps for durability and proper sealing in analytical systems.

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Maintains method integrity and chromatographic consistency

300 Å Wide Pore – Biomolecule Protection

• Designed specifically for:

  • Proteins

  • Peptides

  • Large molecular weight compounds

• Prevents:

  • Restricted diffusion

  • Pore blocking seen with 100 Å media

✅ Essential for biomolecule methods and LC‑MS workflows

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained biomolecules

  • Matrix buildup and fouling

• Extend column lifetime

• Maintain retention consistency and peak shape

• Reduce downtime and replacement costs

10 µm Guard Media – Durability & Compatibility

• Provides robust performance in high‑load analytical workflows

• Ideal for method development and QC environments

• Offers extended guard life compared to smaller particle guards

✅ Supports longer service intervals in demanding workflows

Why Choose Wide Pore Guard Cartridges (10 µm, 300 Å)

Matched Biomolecule Chemistry

• Same wide‑pore C18 chemistry as primary column

• Maintains selectivity and chromatographic behavior

• Prevents unexpected method changes

Enhanced Biomolecule Protection

• Captures large analytes and strongly retained compounds before reaching column

• Reduces column fouling and degradation

Workflow Efficiency

• Minimizes column downtime and maintenance

• Essential for high‑throughput and LC‑MS laboratories

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances reproducibility

High Purity Silica

• Reliable performance across runs

• Consistent guard‑to‑guard quality

Durable Construction

• Stainless steel cartridge body and frits

• PEEK‑based sealing system

• Designed for routine analytical use

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Replace regularly to maintain optimal column performance

• Critical for protecting high‑value analytical columns