Prep HPLC Column, RP PFP, 10um, 100A. 21.2mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
68022-P21-100 Cogent RP PFP™ Prep HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for preparative and scale‑up separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These selectivity advantages help improve separation efficiency and purity during preparative workflows.
With a 10 µm particle size, this column offers very low backpressure compared to smaller particle columns, enabling higher flow rates and improved system compatibility for preparative HPLC systems.
100 mm Length – Balanced Resolution and Throughput
The 100 mm length provides an optimal balance between separation efficiency and purification speed.
Improved resolution compared to 50 mm columns
Faster run times than longer preparative columns
Increased peak capacity for moderately complex mixtures
✅ Recommended for routine purification, scale‑up, and method optimization
Flow Rate & System Requirements (21.2 mm ID, 10 µm)
⚠️ Requires preparative HPLC system capability
Typical flow rate range: ~10 – 30 mL/min
Very low backpressure vs 5 µm and 3 µm columns
Designed for high‑flow preparative operation
Compatible with fraction collectors and preparative detectors
✅ Important: A specialized preparative HPLC system is required for columns of this size
✅ Best Practice: Use appropriate sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain performance
Why Choose PFP (F5) Columns for Preparative Work
Enhanced Selectivity for Complex Mixtures
Strong interaction with halogenated and fluorinated compounds
Improved selectivity vs traditional C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Greater flexibility for purification method development
100 Å Pore Structure
Suitable for small to moderately sized molecules
Consistent behavior from analytical to preparative scale
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and compound recovery
Low Backpressure (10 µm Particles)
Enables high flow rate operation
Reduces strain on preparative systems
High Purity Silica
Reliable and reproducible chromatographic performance
Consistent purification results
Typical Applications
Preparative HPLC purification
Large‑scale compound isolation
Halogenated compound purification
Aromatic compound separations
Pharmaceutical scale‑up workflows
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires preparative HPLC system capability
Designed for high‑flow operation (21.2 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable