Catalog Number - 68022-P21-150

68022-P21-150 Cogent RP PFP™ Prep HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for preparative and scale‑up separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.

The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These mechanisms improve separation of structurally similar compounds, which is critical in preparative purification workflows.

With a 10 µm particle size, this column provides very low backpressure compared to smaller particle columns, enabling higher flow rates and improving system compatibility for preparative HPLC systems.

150 mm Length – Enhanced Resolution with High Flow Capability

The 150 mm length offers increased resolving power while maintaining high‑flow performance.

• Higher resolution than 50 mm and 100 mm formats

• Improved separation of closely related compounds

• Increased peak capacity for moderately complex mixtures

✅ Recommended for purification workflows requiring improved resolution with high throughput

Flow Rate & System Requirements (21.2 mm ID, 10 µm)

⚠️ Requires preparative HPLC system capability

• Typical flow rate range: ~10 – 30 mL/min

• Very low backpressure vs 5 µm and 3 µm columns

• Designed for high‑flow preparative operation

• Compatible with fraction collectors and preparative detectors

✅ Important: A specialized preparative HPLC system is required for columns of this size

✅ Best Practice: Use appropriate sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain performance

Why Choose PFP (F5) Columns for Preparative Work

Enhanced Selectivity for Complex Mixtures

• Strong interaction with halogenated and fluorinated compounds

• Improved selectivity vs C18 columns

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Greater flexibility for purification method development

100 Å Pore Structure

• Suitable for small to moderately sized molecules

• Consistent behavior from analytical to preparative scale

Cogent RP PFP™ Column Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry and recovery

Low Backpressure (10 µm Particles)

• Enables high flow rate operation

• Reduces strain on preparative systems

High Purity Silica

• Reliable and reproducible chromatographic performance

• Consistent results during scale‑up

Typical Applications

• Preparative HPLC purification

• Large‑scale compound isolation

• Halogenated compound purification

• Aromatic compound separations

• Pharmaceutical scale‑up workflows

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Requires preparative HPLC system capability

• Designed for high‑flow operation (21.2 mm ID columns)

Made‑to‑Order Columns & Pricing Information

This is a custom, made‑to‑order column.

• Columns are manufactured specifically to order

• Orders cannot be canceled once placed

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification: Class A Custom Item

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.