Prep HPLC Column, RP PFP, 10um, 100A. 30mm ID x 250mm Length. Cogent Brand. 1 EA.
Additional Info:
68022-P30-250 Cogent RP PFP™ Prep HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering reliable performance and enhanced selectivity for large‑scale preparative and production workflows. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These mechanisms allow for improved separation of closely related compounds, which is critical in high‑purity and complex preparative separations.
With a 10 µm particle size, this column offers extremely low backpressure compared to smaller particle columns, enabling very high flow rates and improved compatibility with large‑diameter preparative HPLC systems.
250 mm Length – Maximum Resolution for Large‑Scale Purification
The 250 mm length delivers the highest resolving power available for 30 mm preparative columns, making it ideal for the most demanding purification challenges.
Maximum resolution vs shorter column formats
Superior separation of co‑eluting and structurally similar compounds
Highest peak capacity for complex mixtures
✅ Recommended for impurity isolation, complex separations, and high‑purity production workflows
Flow Rate & System Requirements (30 mm ID, 10 µm)
⚠️ Requires preparative or process‑scale HPLC system capability
Typical flow rate range: ~20 – 60 mL/min
Extremely low backpressure vs 5 µm and 3 µm columns
Increased pressure due to 250 mm length, but still manageable
Compatible with large‑scale fraction collection systems
✅ Important: A specialized preparative or process‑scale HPLC system is required for columns of this size
✅ Best Practice: Use proper sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain long-term performance
Why Choose PFP (F5) Columns for Preparative Work
Enhanced Selectivity for Complex Mixtures
Strong interaction with halogenated and fluorinated compounds
Improved selectivity vs traditional C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole interactions and hydrogen bonding
Greater flexibility for purification method development
100 Å Pore Structure
Suitable for small to moderately sized molecules
Consistent performance from analytical to large‑scale preparative workflows
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and compound recovery
Ultra‑Low Backpressure (10 µm Particles)
Enables very high flow operation
Reduces system strain in large‑scale HPLC setups
High Purity Silica
Reliable, reproducible chromatographic performance
Consistent purification results at production scale
Typical Applications
Large‑scale preparative HPLC purification
Process-scale compound isolation
Impurity isolation and high‑purity production
Halogenated compound separations
Aromatic compound purification
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires preparative or process‑scale HPLC system capability
Designed for high‑flow operation (30 mm ID columns)
Increased pressure due to longer column length
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable