Process HPLC Column, RP PFP, 10um, 100A. 50mm ID x 50mm Length. Cogent Brand. 1 EA.
Additional Info:
68022-P50-50 Cogent RP PFP™ Process HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering reliable performance and enhanced selectivity for process‑scale and production‑level purification. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it especially effective for halogenated, aromatic, and polar analytes. These interaction mechanisms improve selectivity and enable efficient separation of structurally similar compounds in large‑scale workflows.
With a 10 µm particle size, this column provides extremely low backpressure compared to smaller particle columns, allowing very high flow rates and improved compatibility with process‑scale HPLC systems.
50 mm Length – Fast Process‑Scale Purification
The 50 mm length is optimized for speed and throughput in production environments.
Very fast purification cycles and short run times
Reduced solvent consumption compared to longer columns
Ideal for method scouting and early-stage process development
✅ Recommended for high‑throughput purification and rapid scale‑up
Flow Rate & System Requirements (50 mm ID, 10 µm)
⚠️ Requires process‑scale or pilot‑scale HPLC system capability
Typical flow rate range: ~40 – 150 mL/min
Extremely low backpressure vs 5 µm and 3 µm columns
Designed for ultra high‑flow operation
Compatible with industrial fraction collection systems
✅ Important: A specialized process‑scale HPLC system is required for columns of this size
✅ Best Practice: Use appropriate sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain long‑term performance
Why Choose PFP (F5) Columns for Process‑Scale Work
Enhanced Selectivity for Complex Mixtures
Strong interaction with halogenated and fluorinated analytes
Improved selectivity vs traditional C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Greater flexibility for purification method development
100 Å Pore Structure
Suitable for small to moderately sized molecules
Consistent performance from analytical to full process scale
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and compound recovery
Ultra‑Low Backpressure (10 µm Particles)
Enables very high flow rate operation
Reduces system strain in large‑scale HPLC systems
High Purity Silica
Reliable and reproducible chromatographic performance
Consistent purification results in production environments
Typical Applications
Process‑scale HPLC purification
Pilot‑scale and production compound isolation
Halogenated compound purification
Aromatic compound separations
Pharmaceutical manufacturing and scale‑up
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires process‑scale HPLC system capability
Designed for ultra high‑flow operation (50 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable