Semi Prep HPLC Column, RP PFP, 10um, 100A. 10mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
68022-SP100 Cogent RP PFP™ Semi Prep HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for purification and scale‑up applications. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it especially effective for halogenated, aromatic, and polar analytes. These properties help improve separation of structurally similar compounds during purification workflows.
With a 10 µm particle size, this column offers very low backpressure, enabling higher flow rates and improving compatibility with preparative HPLC systems where throughput and system limitations are important.
100 mm Length – Balanced Resolution and Throughput
The 100 mm length provides an ideal balance between separation efficiency and run time in semi‑prep applications.
Improved resolution compared to 50 mm columns
Faster run times than longer preparative columns
Increased peak capacity for moderately complex mixtures
✅ Recommended for routine purification, method development, and scale‑up
Flow Rate & System Requirements (10 mm ID, 10 µm)
⚠️ Requires semi‑preparative or preparative HPLC system capability
Typical flow rate range: ~3.0 – 6.0 mL/min
Very low backpressure compared to 5 µm and 3 µm columns
Designed for high‑flow preparative operation
Compatible with fraction collectors and preparative detectors
✅ Important: A specialized HPLC system capable of semi‑prep or preparative flow rates is required
✅ Best Practice: Use proper sample filtration and/or guard column protection to maintain column performance
Why Choose PFP (F5) Columns for Semi‑Prep Work
Enhanced Selectivity for Complex Samples
Strong interaction with halogenated and fluorinated compounds
Improved selectivity vs C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Greater flexibility for method scaling and optimization
100 Å Pore Structure
Suitable for small to moderately sized molecules
Balanced performance across purification workflows
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and recovery
Low Backpressure (10 µm Particles)
Enables high flow rate methods
Reduces strain on HPLC systems
High Purity Silica
Consistent and reproducible chromatographic performance
Reliable purification results
Typical Applications
Semi‑prep purification workflows
Method development and scale‑up
Halogenated compound purification
Aromatic compound isolation
Pharmaceutical development and preparative analysis
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires semi‑prep or preparative HPLC system
Designed for high‑flow operation (10 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable