Semi Prep HPLC Column, RP PFP, 10um, 100A. 10mm ID x 50mm Length. Cogent Brand. 1 EA.
Additional Info:
68022-SP50 Cogent RP PFP™ Semi Prep HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for purification and scale‑up workflows. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it especially effective for halogenated, aromatic, and polar analytes. These interactions provide improved selectivity compared to traditional reversed‑phase columns, helping resolve structurally similar compounds during purification.
With a 10 µm particle size, this column operates at very low backpressure, enabling higher flow rates and making it ideal for preparative HPLC systems where throughput and system limitations are important considerations.
50 mm Length – Fast Purification and Method Scouting
The 50 mm length is optimized for rapid separations and high‑throughput purification.
Fast purification cycles and reduced run times
Lower solvent consumption compared to longer columns
Ideal for early-stage method development and scale‑up scouting
✅ Recommended for rapid purification workflows and high‑flow applications
Flow Rate & System Requirements (10 mm ID, 10 µm)
⚠️ Requires semi‑preparative or preparative HPLC system capability
Typical flow rate range: ~3.0 – 6.0 mL/min
Very low backpressure vs smaller particle sizes
Designed for high-flow preparative operation
Compatible with fraction collectors and preparative detectors
✅ Important: A specialized HPLC system capable of semi‑prep or preparative flow rates is required
✅ Best Practice: Use appropriate sample filtration and/or guard column protection to maintain system performance
Why Choose PFP (F5) Columns for Semi‑Prep Work
Enhanced Selectivity for Complex Samples
Strong interaction with halogenated and fluorinated analytes
Improved selectivity vs C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Greater flexibility for method scaling and optimization
100 Å Pore Structure
Suitable for small to moderately sized molecules
Broad applicability in purification workflows
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and compound recovery
Low Backpressure (10 µm Particles)
Ideal for high flow rate methods
Reduces system strain and enables scale‑up
High Purity Silica
Consistent and reproducible chromatographic performance
Reliable purification results
Typical Applications
Semi‑prep purification workflows
Method development and scale‑up
Halogenated compound purification
Aromatic compound isolation
Pharmaceutical development and preparative analysis
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires semi‑prep or preparative HPLC system
Designed for high‑flow operation (10 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable