Catalog Number - 68034-05P

Cogent RP Cyano is a versatile reversed-phase stationary phase designed for HPLC methods requiring lower hydrophobic retention, rapid equilibration, and unique selectivity compared to traditional C18 columns. Manufactured using high-purity silica with a cyanopropyl (CN) bonded phase, it provides balanced retention for polar and moderately hydrophobic compounds while offering compatibility with many USP L10 methods. The cyano functionality can deliver different selectivity than alkyl phases, making it useful during method development and column screening.

68034-05P is an analytical HPLC column packed with 10 µm RP Cyano particles featuring a 100 Å pore size in a 4.6 mm ID x 50 mm format. The short column length is optimized for fast analyses, rapid method development, and scouting studies. The 10 µm particle size supports lower operating backpressure and allows higher flow rates when appropriate. Typical operating flow rates for a 4.6 mm ID column are approximately 1.0–2.0 mL/min depending on mobile phase composition, analyte characteristics, and system configuration.

This column is frequently used for polar and neutral compounds where reduced retention and faster equilibration are desirable. It is also commonly selected for USP L10 methods, method development projects, and preparative method scouting prior to scale-up.

Key Benefits

• RP Cyano stationary phase

• USP L10 column equivalent chemistry

• Cyanopropyl bonded phase

• High-purity silica support

• Alternative selectivity to C18 columns

• Faster equilibration than many traditional reversed-phase columns

• Reduced hydrophobic retention

• Suitable for polar and neutral compounds

• Lower operating backpressure with 10 µm particles

• Useful for method development and scouting

Typical Applications

• USP L10 methods

• Method development

• Preparative method scouting

• Polar compound analysis

• Neutral compound analysis

• Pharmaceutical analysis

• Quality control testing

• Routine HPLC analysis

• Fast separations

• Alternative selectivity screening

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP Cyano

• USP Classification: L10

• Chromatography Mode: Reversed Phase

• Bonded Phase: Cyanopropyl (CN)

• Endcapping: Not Endcapped

• Particle Size: 10 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 50 mm

• Length: 50 mm

• Typical Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Additional Resources

• View Cogent Normal Phase Cyano Columns Packed in Normal Phase Solvents

Important Notes

• Packed and shipped in reversed-phase solvents

• Often used as an alternative selectivity choice to traditional C18 columns

• Short column length is ideal for rapid analyses and method scouting

• Commonly used for polar and neutral compounds

• Suitable for transferring promising methods to larger-scale columns

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