Catalog Number - 68034-10P

Cogent RP Cyano is a versatile reversed-phase stationary phase designed for HPLC methods requiring lower hydrophobic retention, rapid equilibration, and selectivity different from traditional C18 columns. Manufactured using high-purity silica with a cyanopropyl (CN) bonded phase, it provides balanced retention for polar and moderately hydrophobic compounds while serving as an effective alternative for USP L10 methods. The unique cyano functionality often provides different separation characteristics than alkyl phases, making it valuable for method development and selectivity screening.

68034-10P is an analytical HPLC column packed with 10 µm RP Cyano particles featuring a 100 Å pore size in a 4.6 mm ID x 100 mm format. The 100 mm length provides increased resolving power compared to shorter columns while maintaining reasonable analysis times. The 10 µm particle size supports lower operating backpressure and allows higher flow rates when appropriate. Typical operating flow rates are approximately 1.0–2.0 mL/min depending on mobile phase composition, analyte characteristics, and instrument configuration.

This column is commonly used for polar and neutral compounds where reduced retention and faster equilibration are beneficial. It is frequently selected for USP L10 methods, pharmaceutical analysis, quality control applications, and method development projects requiring alternative reversed-phase selectivity.

Key Benefits

• RP Cyano stationary phase

• USP L10 column equivalent chemistry

• Cyanopropyl bonded phase

• High-purity silica support

• Alternative selectivity to C18 columns

• Faster equilibration than many traditional reversed-phase columns

• Reduced hydrophobic retention

• Suitable for polar and neutral compounds

• Lower operating backpressure with 10 µm particles

• Excellent for method development and selectivity screening

Typical Applications

• USP L10 methods

• Pharmaceutical analysis

• Method development

• Quality control testing

• Polar compound analysis

• Neutral compound analysis

• Alternative selectivity screening

• Routine HPLC analysis

• Impurity profiling

• Preparative method scouting

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP Cyano

• USP Classification: L10

• Chromatography Mode: Reversed Phase

• Bonded Phase: Cyanopropyl (CN)

• Endcapping: Not Endcapped

• Particle Size: 10 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Typical Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Additional Resources

• View Cogent Normal Phase Cyano Columns Packed in Normal Phase Solvents

Important Notes

• Packed and shipped in reversed-phase solvents

• Commonly used as an alternative selectivity choice to traditional C18 columns

• Increased column length provides improved resolution compared to shorter formats

• Frequently selected for USP L10 methods

• Useful for preparative method scouting and method transfer

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