Catalog Number - 68039-05P

Cogent RP Phenyl Hexyl is a highly selective reversed-phase stationary phase designed for enhanced aromatic compound separations. Manufactured on high-purity silica with a fully double endcapped phenyl hexyl (C6-Phenyl) bonded phase, it combines hydrophobic retention with strong π-π interactions. The extended six-carbon linker positions the phenyl ring farther from the silica surface, reducing silanol influence and often providing different selectivity than conventional phenyl phases. This chemistry is commonly used as an alternative for certain USP L11 methods and for challenging aromatic compound separations.

68039-05P is an analytical HPLC column packed with 10 µm RP Phenyl Hexyl particles featuring a 100 Å pore size in a 4.6 mm ID x 50 mm format. The short column length is optimized for rapid analyses, fast method development, and preparative method scouting. The 10 µm particle size supports higher flow rates with lower operating backpressure, making it ideal for efficient screening applications. Typical operating flow rates are approximately 1.0–2.0 mL/min depending on mobile phase composition, analyte characteristics, and system configuration.

This column is particularly effective for aromatic compounds, positional isomers, tocopherols, flavonoids, polynuclear aromatic compounds, nitro-aromatic compounds, active pharmaceutical ingredients (APIs), natural products, and related compounds containing aromatic rings. For enhanced π-π interactions and selectivity, methanol is often preferred over acetonitrile as the organic modifier.

Key Benefits

• RP Phenyl Hexyl stationary phase

• USP L11 alternative chemistry

• C6-Phenyl bonded phase

• Fully double endcapped

• High-purity silica support

• Enhanced π-π interaction selectivity

• Reduced silanol interaction effects

• Alternative selectivity to conventional phenyl columns

• Lower operating backpressure with 10 µm particles

• Excellent preparative method scouting column

Typical Applications

• USP L11 methods

• Aromatic compound analysis

• Positional isomer separations

• Active pharmaceutical ingredient (API) analysis

• Flavonoid analysis

• Tocopherol analysis

• Polynuclear aromatic compound separations

• Nitro-aromatic compound analysis

• Natural product analysis

• Preparative method scouting

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP Phenyl Hexyl

• USP Classification: L11 Alternative

• Chromatography Mode: Reversed Phase

• Bonded Phase: Phenyl Hexyl (C6-Phenyl)

• Endcapping: Fully Double Endcapped

• Particle Size: 10 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 50 mm

• Length: 50 mm

• Typical Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Additional Resources

• View Specifications of Cogent Reversed Phase Columns

Important Notes

• Often selected as an alternative for USP L11 methods

• Extended C6 linker can provide different selectivity than conventional phenyl phases

• Methanol is often preferred over acetonitrile to maximize π-π interactions

• Short column length is ideal for rapid analyses and method development

• Compare performance to Restek Phenyl Hexyl columns

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