Catalog Number - 68124-05P

Cogent RP Phenyl™ is a reversed-phase UHPLC stationary phase designed to provide enhanced selectivity for aromatic and structurally related compounds. Manufactured using a propyl linker with a terminal phenyl ring bonded to ultra-high purity silica and fully double end capped, this phase offers unique π-π interactions that can improve separation of compounds that may be difficult to resolve on traditional alkyl phases. It is particularly useful for aromatic pharmaceuticals, positional isomers, flavonoids, tocopherols, polynuclear aromatic hydrocarbons, nitro-aromatic compounds, and many natural products.

68124-05P is a UHPLC column packed with 1.8 µm RP Phenyl™ particles featuring a 100 Å pore size in a 4.6 mm ID x 50 mm format. The short 50 mm length is optimized for fast analyses and high sample throughput, while the sub-2 µm particle technology provides exceptional efficiency, increased peak capacity, and excellent chromatographic performance. Designed specifically for high-pressure UHPLC applications, this column delivers optimal performance when used on UHPLC systems capable of operating at the elevated pressures generated by 1.8 µm particles. Typical operating flow rates are approximately 1.0–2.0 mL/min.

This column is ideal for rapid analysis of aromatic compounds, positional isomers, APIs, and natural products when improved selectivity or shorter run times are desired. While compatible HPLC systems may be used if pressure limitations allow, this column is engineered primarily for UHPLC operation where the benefits of sub-2 µm particles can be fully realized.

Key Benefits

• RP Phenyl™ stationary phase

• Fully double end capped

• Propyl phenyl bonded phase

• Ultra-high purity silica support

• Enhanced aromatic selectivity

• π-π interaction capability

• Engineered for UHPLC applications

• High-efficiency 1.8 µm particles

• Fast analysis times

• Reduced solvent consumption

Typical Applications

• Positional isomer separations

• Tocopherol analysis

• Flavonoid analysis

• Polynuclear aromatic hydrocarbon analysis

• Nitro-aromatic compound analysis

• API analysis

• Natural product analysis

• Pharmaceutical method development

• UHPLC analysis

• High-throughput laboratories

Specifications

• Product Type: UHPLC Column

• Stationary Phase: RP Phenyl™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Propyl Phenyl

• Endcapping: Fully Double End Capped

• Particle Size: 1.8 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 50 mm

• Length: 50 mm

• Typical Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed specifically for UHPLC operation and high-pressure reversed-phase chromatography

• 1.8 µm particles generate substantially higher backpressure than conventional HPLC columns

• Maximum performance is achieved on UHPLC systems designed for sub-2 µm particle technology

• Enhanced selectivity for aromatic compounds compared to traditional alkyl phases

• Excellent choice for improving resolution of positional isomers and phenyl-containing compounds

• Samples should be filtered through a 0.2 µm syringe filter prior to injection

• May be used on compatible HPLC systems only if instrument pressure limits are not exceeded

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