Catalog Number - 68134-10P

Cogent RP Cyano™ is a versatile reversed-phase UHPLC stationary phase designed for polar and neutral compound separations where reduced retention and rapid equilibration are desired. Manufactured with a cyanopropyl bonded phase on ultra-high purity silica and supplied without endcapping, this chemistry provides distinct selectivity compared to traditional alkyl phases. RP Cyano™ is commonly used as an alternative for USP L10 methods and offers shorter retention times than many conventional reversed-phase columns while maintaining excellent chromatographic performance.

68134-10P is a UHPLC column packed with 1.8 µm RP Cyano™ particles featuring a 100 Å pore size in a 4.6 mm ID x 100 mm format. The 100 mm length provides increased resolution and peak capacity compared to shorter 50 mm columns, while the sub-2 µm particle technology delivers exceptional efficiency and chromatographic performance. This column is specifically engineered for high-pressure UHPLC applications and is designed to take full advantage of UHPLC instrumentation capable of operating at the elevated pressures generated by 1.8 µm particles. Typical operating flow rates are approximately 1.0–2.0 mL/min depending on method conditions and system pressure limitations.

This column is particularly useful for polar and neutral compounds requiring reversed-phase retention with fast equilibration and efficient separations. The increased column length makes it an excellent choice when additional resolution is needed while maintaining the unique selectivity offered by RP Cyano™ chemistry.

Key Benefits

• RP Cyano™ stationary phase

• USP L10 equivalent chemistry

• Cyanopropyl bonded phase

• Ultra-high purity silica support

• Designed for UHPLC applications

• High-efficiency 1.8 µm particles

• Unique selectivity compared to C8 and C18 phases

• Shorter retention times for many analytes

• Rapid equilibration between runs

• Enhanced resolution with 100 mm column length

Typical Applications

• USP L10 methods

• UHPLC analysis

• Polar compound analysis

• Neutral compound analysis

• Pharmaceutical analysis

• Method development

• Impurity profiling

• Fast reversed-phase separations

• Quality control testing

• Complex sample analysis

Specifications

• Product Type: UHPLC Column

• Stationary Phase: RP Cyano™

• USP Classification: L10

• Chromatography Mode: Reversed Phase

• Bonded Phase: Cyanopropyl

• Endcapping: Not Endcapped

• Particle Size: 1.8 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Typical Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed specifically for UHPLC operation and high-pressure reversed-phase chromatography

• 1.8 µm particles generate substantially higher backpressure than conventional HPLC columns

• Maximum performance is achieved on UHPLC systems designed for sub-2 µm particle technology

• May be used on compatible HPLC systems only if instrument pressure limits are not exceeded

• Packed and shipped in reversed-phase solvents

• For Cogent NP Cyano Columns packed in Normal Phase solvents, view the Normal Phase product line

• The 100 mm length provides greater resolution and peak capacity than 50 mm columns

• Samples should be filtered through a 0.2 µm syringe filter prior to injection

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