Catalog Number - 68318-PG2

The 68318‑PG2 Cogent RP C18 Guard Column Cartridges are designed to extend the life of analytical HPLC columns, delivering high‑efficiency protection against particulates, strongly retained analytes, and sample matrix contamination in demanding workflows.

Packed with 3 µm Cogent RP C18™ stationary phase and manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, these cartridges are fully double end‑capped to provide:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• High‑efficiency chromatographic protection that matches modern analytical columns

Each cartridge is constructed in a stainless steel housing with stainless steel frits, secured with PEEK frit caps to ensure durability and leak‑free performance.

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Maintains chromatographic selectivity and method integrity

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained compounds

  • Sample matrix buildup and fouling

• Extend column lifetime

• Maintain retention time stability and peak shape

• Reduce downtime and column replacement cost

3 µm Guard Media – High‑Efficiency Protection

• Matches high‑efficiency analytical column particles

• Preserves resolution and chromatographic performance

• Ideal for method development, QC, and regulated workflows

✅ Provides maximum protection with minimal impact on efficiency

Why Choose RP C18 Guard Cartridges (3 µm, 4.0 mm)

Matched Analytical Chemistry

• Same C18 stationary phase as primary column

• Maintains method selectivity and reproducibility

• Prevents chromatographic variation

Enhanced Column Protection

• Captures contaminants before reaching the analytical column

• Reduces irreversible binding and column degradation

Improved Workflow Efficiency

• Minimizes column downtime and replacement frequency

• Supports high‑throughput analytical laboratories

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances reproducibility

High Purity Silica

• Reliable performance across injections

• Consistent guard‑to‑guard quality

Durable Construction

• Stainless steel cartridge body and frits

• PEEK sealing components

• Designed for routine analytical use

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed for analytical HPLC systems (3.0–4.6 mm ID columns)

• Replace regularly to maintain optimal chromatographic performance

• Essential for protecting high‑value analytical columns