Guard Column Cartridges, RP PFP, 3um, 100A. 2.1mm ID x 10mm Length. Cogent Brand. 5/PK.
Additional Info:
68322-PG1 Cogent RP PFP™ Guard Column Cartridges are designed to protect narrow‑bore analytical and UHPLC columns from particulates and strongly retained contaminants that can reduce column efficiency and lifespan. Packed with 3 µm Cogent RP PFP™ material, these cartridges provide high efficiency and matched selectivity for RP PFP analytical methods.
The packing material is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica. This ensures consistent chromatographic behavior and seamless integration with RP PFP analytical columns.
Each cartridge is housed in a stainless steel tube with stainless steel frits pressed into PEEK frit caps, providing durability and compatibility with UHPLC and low‑flow systems.
2.1 mm ID × 10 mm Length – UHPLC & LC‑MS Column Protection
Optimized for narrow‑bore column formats, these guard cartridges provide effective protection with minimal dispersion.
Designed for 2.1 mm ID analytical columns
Minimizes band broadening in low‑volume systems
Protects against particulates and matrix contamination
Maintains analytical resolution and sensitivity
✅ Recommended for UHPLC and LC‑MS workflows requiring low dispersion and high efficiency
Flow Rate & System Requirements (2.1 mm ID, 3 µm)
⚠️ Requires UHPLC or LC‑MS capable system with reliable low‑flow performance
Typical flow rate range: ~0.2 – 0.4 mL/min
Higher backpressure vs larger particle sizes
Optimized for high‑efficiency, low‑flow separations
Compatible with MS detectors and low‑volume systems
✅ Important: Standard HPLC systems must be capable of stable low‑flow operation to use 2.1 mm ID columns effectively
✅ Required Hardware: Must be used with a guard column holder designed for 2.1 mm analytical cartridges (see guard column holder product page for compatibility and system configuration)
Why Use RP PFP Guard Columns
Column Protection
Prevents contamination from particulates and sample matrix
Reduces irreversible adsorption on analytical columns
Maintains Selectivity
Matches RP PFP column chemistry
Ensures consistent analytical results
Preserves Efficiency
Minimizes dispersion in UHPLC systems
Extends column life in high‑sensitivity workflows
Cogent RP PFP™ Guard Cartridge Advantages
Matched Chemistry
Same selectivity as RP PFP analytical columns
High Efficiency (3 µm Particles)
Ideal for UHPLC and LC‑MS applications
Maintains peak shape and resolution
Durable Construction
Stainless steel body with PEEK-end capped frits
Typical Applications
UHPLC and LC‑MS workflows
High‑sensitivity analytical separations
Halogenated compound analysis
Aromatic compound separations
Pharmaceutical and bioanalytical testing
Important Usage Notes
Must be used with a compatible 2.1 mm ID guard column holder
Designed for low‑flow UHPLC and LC‑MS systems
Packed and shipped in reversed‑phase solvents
Replace guard cartridges regularly to maintain optimal performance