HPLC Column, RP Cyano, 3um, 4.0mm ID x 250mm Length, 100A. Cogent Brand. 1 EA. Special Order Item.
Additional Information:
Cogent RP Cyano™ is a versatile reversed-phase HPLC stationary phase designed for the separation of polar and neutral compounds. Manufactured using a three-carbon ligand with a terminal cyano (CN) functional group bonded to ultra-high purity silica, this stationary phase provides selectivity distinct from traditional C18, C8, and phenyl phases. As a USP L10 equivalent phase, it is widely used for method replacement, method development, and applications requiring reduced hydrophobic retention, faster equilibration, and alternative selectivity.
68334-25P-4 is an HPLC column packed with 3 µm RP Cyano™ particles featuring a 100 Å pore size in a 4.0 mm ID x 250 mm format. The 250 mm length provides maximum chromatographic resolution and peak capacity within the RP Cyano product family, while the 3 µm particles provide greater efficiency and sharper peaks than comparable 5 µm columns. Typical operating flow rates are approximately 0.8–1.5 mL/min depending on mobile phase composition, temperature, and system configuration.
Often selected for polar and neutral compounds in reversed-phase HPLC, this Cyano phase typically provides shorter retention times and faster equilibration than non-modified silica columns. The extended 250 mm length offers exceptional resolving power for complex separations, impurity profiling, stability-indicating methods, and USP L10 applications where maximum resolution is required.
Key Benefits
RP Cyano™ stationary phase
USP L10 equivalent chemistry
Cyano bonded phase
Ultra-high purity silica support
Alternative selectivity to C18 and C8 phases
Faster equilibration between runs
Shorter retention for many compounds
3 µm particle size
Greater efficiency than 5 µm columns
Maximum chromatographic resolution
Typical Applications
USP L10 methods
Polar compound analysis
Neutral compound analysis
Reversed-phase HPLC
Pharmaceutical analysis
Method development
Stability-indicating methods
Impurity profiling
Quality control testing
Research and development
Specifications
Product Type: HPLC Column
Stationary Phase: RP Cyano™
USP Classification: L10
Chromatography Mode: Reversed Phase
Bonded Phase: Cyano (CN)
Endcapping: Not End Capped
Particle Size: 3 µm
Pore Size: 100 Å
Column Dimensions: 4.0 mm ID x 250 mm
Length: 250 mm
Typical Flow Rate: 0.8–1.5 mL/min
Brand: Cogent
Special Order Item Information
Please review the Special Order Item Information for complete details.
For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.
Important Notes
Designed for reversed-phase HPLC applications
Provides alternative selectivity compared to C18, C8, and Phenyl phases
Suitable for polar and neutral compounds
Faster equilibration than many traditional reversed-phase columns
The 250 mm length provides maximum resolution and peak capacity for demanding separations
3 µm particles provide higher efficiency and sharper peaks than comparable 5 µm columns
Generates higher backpressure than larger particle columns
Particularly useful for impurity profiling and complex sample matrices
Packed and shipped in reversed-phase solvents
For normal-phase applications, view the related Cogent NP Cyano Columns packed in Normal Phase solvents
This is a Special Order Item