Catalog Number - 68508-SP-PG1-3

Cogent RP C8™ Wide Pore Semi-Preparative Guard Column Cartridges are designed to protect valuable semi-preparative HPLC columns from particulates, strongly retained compounds, proteins, peptides, and other sample contaminants that can reduce column performance and shorten column life. Packed with the same RP C8™ Wide Pore stationary phase used in Cogent semi-preparative columns, these guard cartridges help maintain chromatographic consistency while extending column service life. The stationary phase consists of an octyl (C8) bonded ligand attached to ultra-high purity silica and is fully double end capped to provide reproducible reversed-phase performance.

68508-SP-PG1-3 is a semi-preparative guard column cartridge packed with 5 µm RP C8™ Wide Pore particles featuring a 300 Å pore size in a 10 mm ID x 10 mm format. Designed specifically to protect RP C8™ Wide Pore semi-preparative columns, these cartridges capture particulates and contaminants before they reach the primary column bed. The 300 Å pore structure provides enhanced accessibility for proteins, peptides, biomolecules, and other higher molecular weight compounds. Constructed from stainless steel tubing with stainless steel frits, they provide durability and reliable performance in purification, fraction collection, and scale-up applications.

Routine replacement of guard cartridges helps maintain column efficiency, preserve chromatographic performance, and reduce the cost of replacing larger semi-preparative columns. These cartridges are particularly beneficial for protein purification, peptide purification, biomolecule isolation, method development, and analytical-to-semi-preparative scale-up workflows.

Key Benefits

• RP C8™ Wide Pore stationary phase

• Octyl (C8) bonded phase

• Fully double end capped

• Ultra-high purity silica support

• 300 Å wide pore design

• Protects semi-preparative HPLC columns

• Ideal for proteins and peptides

• Extends column lifetime

• Maintains chromatographic performance

• Supplied in convenient 5-pack format

Typical Applications

• Semi-preparative HPLC

• Protein purification

• Peptide purification

• Biomolecule purification

• Fraction collection

• Method scale-up

• Biopharmaceutical purification

• Pharmaceutical purification

• Process development

• Column protection

Specifications

• Product Type: Semi-Preparative Guard Column Cartridge

• Stationary Phase: RP C8™ Wide Pore

• Chromatography Mode: Reversed Phase

• Bonded Phase: Octyl (C8)

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 300 Å

• Cartridge Dimensions: 10 mm ID x 10 mm

• Construction: Stainless Steel Tube with Stainless Steel Frits

• Quantity: 5/PK

• Brand: Cogent

Special Order Item Information

• Please review the Special Order Item Information for complete details.

• For pricing confirmation, availability, lead times, or application assistance, please contact MICROSOLV Customer Service.

Important Notes

• Designed to protect RP C8™ Wide Pore semi-preparative HPLC columns from particulates and contaminants

• 300 Å pores provide enhanced accessibility for proteins, peptides, and biomolecules

• Helps extend column service life and maintain chromatographic performance

• Suitable for purification and scale-up workflows involving larger molecules

• Constructed with durable stainless steel hardware

• A specialized semi-preparative HPLC system is recommended for columns of this size

• A Cogent 10 mm ID Semi-Preparative Guard Column Holder (83000-SP-GH) is required for use with these guard column cartridges

• Compatible with Cogent RP C8™ Wide Pore 10 mm ID semi-preparative columns

• Helps reduce the cost of replacing larger semi-preparative columns

• Supplied as a package of five replacement cartridges

• This is a Special Order Item