Catalog Number - 68512-15P

Cogent RP C12™ HPLC Columns are designed for reversed-phase separations requiring unique selectivity, rapid equilibration, and reproducible retention. The stationary phase is manufactured using a rigid adamantane-shaped carbon silane ligand bonded to ultra-high purity silica and fully double end capped to minimize secondary interactions. This distinctive bonded phase chemistry offers chromatographic behavior between traditional C8 and C18 phases, making it especially useful for complex mixtures, USP methods, and analytical method development.

68512-15P is packed with 5 µm RP C12™ particles featuring a 100 Å pore size in a 4.6 mm ID x 150 mm format. The 150 mm column length provides enhanced resolving power and peak capacity compared to shorter columns, making it well suited for more demanding separations. The RP C12™ phase typically provides less retention than C18 columns but greater retention than C8 columns for many hydrophobic compounds, offering an alternative selectivity profile that can improve challenging analyses. The stationary phase is also compatible with highly aqueous mobile phases, including 100% water, without phase collapse or loss of retention.

The 4.6 mm ID x 150 mm format is one of the most widely used analytical column configurations for routine HPLC, pharmaceutical analysis, USP methods, and quality control applications. Typical flow rates are approximately 0.8-1.5 mL/min depending on method requirements and mobile phase conditions.

Key Benefits

• RP C12™ stationary phase

• Adamantane-shaped bonded ligand

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• Unique selectivity profile

• Compatible with 100% aqueous mobile phases

• Rapid column equilibration

• Enhanced chromatographic resolution

• Popular choice for USP methods

Typical Applications

• Reversed-phase HPLC

• USP methods

• Pharmaceutical analysis

• Method development

• Quality control testing

• High-throughput screening (HTS)

• Complex mixture separations

• Hydrophobic compound analysis

• Research and development

• Routine analytical HPLC

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C12™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Adamantane-Shaped C12 Ligand

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 150 mm

• Recommended Flow Rate: 0.8-1.5 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Provides a selectivity profile between traditional C8 and C18 phases

• Compatible with highly aqueous and 100% water mobile phases

• Rapid equilibration minimizes time between injections

• 150 mm length provides increased resolution and peak capacity

• Excellent choice for complex mixtures and challenging separations

• Commonly used for USP methods and pharmaceutical analyses

• Suitable for routine analytical and quality control applications

• Useful for method development requiring alternative selectivity

• 4.6 mm ID format is compatible with most standard HPLC systems