Catalog Number - 68518-P30-100

The 68518‑P30‑100 Cogent RP C18 Preparative HPLC Column is designed for production‑scale purification and method development, utilizing 5 µm particles and fully double end‑capped C18 bonding to deliver reliable retention, extremely high loading capacity, and consistent chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible purification results in large‑scale workflows

This column is ideal as a USP L1 alternate and as a refinement platform for scaling purification methods to full production.

100 mm Length – Increased Resolution for Production Development

• Higher resolving power than 50 mm scouting columns

• Improved separation of closely related compounds

• Increased peak capacity for preparative purification workflows

• Ideal for refining methods prior to longer columns or production runs

This configuration is selected when additional resolution is required beyond initial production‑scale scouting.

30 mm ID – Maximum Production‑Scale Loading

• Provides extremely high sample loading capacity

• Designed for large‑scale purification and manufacturing workflows

• Supports very high‑flow preparative chromatography systems

Typical Flow Rate Range

• ~20–60 mL/min (system dependent)

• Optimize based on instrument capability and production requirements

✅ Designed for production‑scale HPLC systems with high flow rates and large injection volumes

Flow Rate & System Considerations (30 mm ID, 5 µm)

• Requires systems capable of:

  • Very high flow rates

  • Large injection volumes

• Compatible with:

  • Production preparative pumps

  • Large‑volume injection systems

  • High‑capacity fraction collection systems

⚠️ Not suitable for analytical or semi‑prep HPLC systems

Why Choose RP C18 (5 µm, Production Scale)

Method Development to Production Scale

• Ideal for refining purification methods prior to full manufacturing runs

• Supports efficient scale‑up from prep to production systems

• Enables consistent process development workflows

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

USP Method Compatibility

• Suitable for USP L1 methods

• Reliable for regulated and validated environments

• Supports method transfer across all scales

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across batches and production runs

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load production workflows

• Reduced maintenance and downtime

Typical Application

• Production‑scale purification

• Method development and refinement

• Hydrophobic and neutral compound isolation

• Pharmaceutical manufacturing

• Process scale‑up workflows

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for 30 mm production‑scale HPLC systems

• Requires very high‑flow capability and large sample loading volumes

• Ideal for method refinement prior to extended production runs

• Optimize for resolution vs throughput balance

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.