Catalog Number - 68518-P30-150

The 68518‑P30‑150 Cogent RP C18 Preparative HPLC Column is engineered for high‑resolution purification and production‑scale method development, utilizing 5 µm particles and fully double end‑capped C18 bonding to deliver consistent retention, extremely high loading capacity, and reliable chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Reproducible purification performance in large‑scale workflows

This column is ideal as a USP L1 alternate and as a high‑performance platform for scaling purification processes to production level.

150 mm Length – Maximum Resolution for Production Purification

• Higher resolving power than 50 mm and 100 mm production columns

• Maximizes peak capacity for complex mixtures

• Ideal for closely related compounds and difficult separations

• Preferred for final purification prior to full‑scale manufacturing

• Longer run times compared to shorter columns

This configuration is selected when maximum separation performance is required before production deployment or continuous processing.

30 mm ID – Maximum Production‑Scale Loading

• Provides extremely high sample loading capacity

• Designed for large‑scale purification and manufacturing workflows

• Supports very high‑flow preparative chromatography systems

Typical Flow Rate Range

• ~20–60 mL/min (system dependent)

• Optimize based on instrument capability and production requirements

✅ Designed for production‑scale HPLC systems with high flow and large injection volumes

Flow Rate & System Considerations (30 mm ID, 5 µm)

• Requires systems capable of:

  • Very high flow rates

  • Large injection volumes

• Compatible with:

  • Production preparative pumps

  • Large‑volume injection systems

  • High‑capacity fraction collection systems

⚠️ Not suitable for analytical or semi‑prep HPLC systems

Why Choose RP C18 (5 µm, Production Scale)

Maximum Resolution for Production Workflows

• Ideal for final purification of complex mixtures at scale

• Maximizes separation performance and product purity

• Supports high‑purity manufacturing processes

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids and similar analytes

• Provides greater retention than C8 phases

USP Method Compatibility

• Suitable for USP L1 methods

• Reliable for regulated production environments

• Supports method transfer across analytical, semi‑prep, and prep scales

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across production batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load production workflows

• Reduced downtime and replacement costs

Typical Applications

• Production‑scale purification

• High‑purity compound isolation

• Complex mixture separations

• Pharmaceutical manufacturing and QC

• Process scale‑up and optimization

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for 30 mm production‑scale HPLC systems

• Requires very high‑flow capability and large sample loading volumes

• Ideal for maximum‑resolution, high‑purity workflows prior to manufacturing

• Optimize for resolution vs throughput balance

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.