Catalog Number - 68518-P30-50

The 68518‑P30‑50 Cogent RP C18 Preparative HPLC Column is designed for production‑scale purification and preparative method development, utilizing 5 µm particles and fully double end‑capped C18 bonding to deliver reliable retention, very high loading capacity, and consistent chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Reproducible purification performance across large‑scale runs

This column is ideal as a USP L1 alternate and as a high‑throughput platform for preparative and production chromatography workflows.

50 mm Length – Fast Production‑Scale Scouting

• Designed for rapid separations and short cycle times

• Ideal for early‑stage production method screening

• Minimizes solvent use during high‑volume purification development

• Enables high‑throughput batch purification workflows

30 mm ID – Maximum Production‑Scale Loading

• Provides extremely high sample loading capacity

• Designed for large‑scale and manufacturing‑level purification

• Supports very high‑flow preparative chromatography systems

Typical Flow Rate Range

• ~20–60 mL/min (system dependent)

• Optimize based on instrument capability and production requirements

✅ Designed for production‑scale HPLC systems with high flow and large injection capacity

Flow Rate & System Considerations (30 mm ID, 5 µm)

• Requires systems capable of:

  • Very high flow rates

  • Large injection volumes

• Compatible with:

  • Production preparative pumps

  • Large‑volume injection systems

  • High‑capacity fraction collection systems

⚠️ Not suitable for analytical or semi‑prep HPLC systems

Why Choose RP C18 (5 µm, Production Scale)

High‑Throughput Purification Platform

• Ideal for large‑scale compound isolation and batch processing

• Maximizes throughput and loading capacity

• Enables efficient scale‑up from prep to production

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for lipids and long‑chain fatty acids

• Provides greater retention than C8 phases

USP Method Compatibility

• Suitable for USP L1 methods

• Reliable for regulated manufacturing environments

• Supports method transfer across all HPLC scales

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load production workflows

• Reduced downtime and replacement cost

Typical Applications

• Production‑scale HPLC purification

• High‑throughput compound isolation

• Hydrophobic and neutral compound separations

• Pharmaceutical manufacturing

• Process development and scale‑up

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for 30 mm ID production‑scale HPLC systems

• Requires very high‑flow capability and large injection capacity

• Ideal for fast production screening and purification workflows

• Optimize for throughput vs resolution balance

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.