Process HPLC Column, RP C18, 5um, 100A. 50mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68518‑P50‑100 Cogent RP C18 Process HPLC Column is designed for industrial‑scale purification and process chromatography development, utilizing 5 µm particles and fully double end‑capped C18 bonding to deliver extreme loading capacity, reliable retention, and consistent large‑scale chromatographic performance.
Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:
Complete end‑capping to minimize silanol interactions
Improved peak symmetry for polar and basic analytes
Reproducible performance across large‑volume and continuous purification runs
This column is ideal as a USP L1 alternate and as a refinement platform for scaling purification processes into full production environments.
100 mm Length – Increased Resolution for Process Development
Higher resolving power than 50 mm process scouting columns
Improves separation of closely related compounds
Increases peak capacity for industrial purification workflows
Ideal for refining methods prior to longer columns or full production runs
This configuration is selected when additional resolution is required beyond initial process‑scale screening.
50 mm ID – Industrial‑Scale Loading Capacity
Provides extremely high sample loading capacity (beyond prep scale)
Designed for process‑scale and manufacturing‑level purification
Supports ultra‑high‑flow chromatography systems
Typical Flow Rate Range
~50–150 mL/min (system dependent)
Optimize based on process requirements and system capability
✅ Designed for process HPLC systems with ultra‑high flow rates and very large injection volumes
Flow Rate & System Considerations (50 mm ID, 5 µm)
Requires systems capable of:
Ultra‑high flow rates
Very large injection volumes
Compatible with:
Process‑scale chromatography systems
Industrial pumps and injection platforms
Large‑volume fraction collection or continuous processing systems
⚠️ Not suitable for analytical, semi‑prep, or standard preparative HPLC systems
Why Choose RP C18 (5 µm, Process Scale)
Method Development to Manufacturing
Ideal for refining purification workflows before full production deployment
Enables efficient scale‑up from preparative to process chromatography
Supports consistent method transfer across all HPLC scales
Reliable Hydrophobic Retention
Strong reversed‑phase retention for hydrophobic and neutral compounds
Effective for lipids and long‑chain fatty acids
Provides greater retention than C8 phases
USP Method Compatibility
Suitable for USP L1 methods
Reliable for regulated industrial environments
Supports validated process development and manufacturing workflows
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Stabilizes chromatographic performance at large scale
High Purity Silica
Consistent chromatographic results
Reduced variability across large‑batch production runs
Durable & Cost‑Efficient
Long column lifetime
Designed for high‑load and continuous processing workflows
Reduced downtime and operational cost
Typical Applications
Process‑scale purification
Industrial manufacturing workflows
High‑throughput compound isolation
Pharmaceutical production
Process development and optimization
USP L1 reversed‑phase methods
Important Usage Notes
Designed for 50 mm process‑scale HPLC systems
Requires ultra‑high‑flow capability and very large sample loading volumes
Ideal for method refinement prior to extended production runs
Optimize for resolution vs throughput based on production goals
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable