Catalog Number - 68518-P50-50

The 68518‑P50‑50 Cogent RP C18 Process HPLC Column is engineered for industrial‑scale purification and process chromatography applications, utilizing 5 µm particles and fully double end‑capped C18 bonding to deliver extreme loading capacity, reliable retention, and consistent large‑scale performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Reproducible performance across large‑volume purification runs

This column is ideal as a USP L1 alternate and as a foundation platform for process‑level purification and manufacturing workflows.

50 mm Length – High‑Throughput Process Scouting

• Designed for rapid separations and short cycle times

• Ideal for early‑stage process method development

• Reduces solvent consumption during large‑scale screening

• Enables high‑throughput purification and process optimization

50 mm ID – Industrial‑Scale Loading Capacity

• Provides extremely high sample loading capacity (beyond prep scale)

• Designed for process‑scale and manufacturing‑level purification

• Supports very high‑flow chromatography systems

Typical Flow Rate Range

• ~50–150 mL/min (system dependent)

• Optimize based on process requirements and system capability

✅ Designed for process HPLC systems with ultra‑high flow rates and large injection volumes

Flow Rate & System Considerations (50 mm ID, 5 µm)

• Requires systems capable of:

  • Ultra‑high flow rates

  • Very large injection volumes

• Compatible with:

  • Process‑scale chromatography systems

  • Industrial pumps and injection systems

  • Large‑volume fraction collection or continuous processing setups

⚠️ Not suitable for analytical, semi‑prep, or standard preparative HPLC systems

Why Choose RP C18 (5 µm, Process Scale)

Industrial‑Scale Purification Platform

• Designed for process and production‑level workflows

• Maximizes throughput and compound output

• Enables efficient scale‑up from prep to manufacturing

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Effective for lipids and long‑chain fatty acids

• Provides greater retention than C8 phases

USP Method Compatibility

• Suitable for USP L1 methods

• Reliable for regulated manufacturing environments

• Supports method transfer across all HPLC scales

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Stabilizes chromatographic performance at scale

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across large‑scale production batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for continuous and high‑load process workflows

• Reduces downtime and operational cost

Typical Applications

• Process‑scale purification

• Industrial manufacturing workflows

• High‑throughput compound isolation

• Pharmaceutical production

• Continuous or batch processing

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for 50 mm process‑scale HPLC systems

• Requires ultra‑high flow capability and very large sample loading volumes

• Ideal for rapid process development and large‑scale purification

• Optimize for throughput vs resolution depending on production goals

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.