Guard Column Cartridges, RP C18 Wide Pore, 5um, 300A. 4.0mm ID x 10mm Length. Cogent Brand. 5/PK.
Additional Info:
The 68518‑PG2‑3 Cogent RP C18 Wide Pore Guard Column Cartridges are designed to extend the life of analytical HPLC columns used in biomolecule workflows, providing effective protection against particulates, strongly retained compounds, and sample matrix fouling.
Packed with 5 µm Cogent RP C18™ Wide Pore stationary phase (300 Å) and manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, these cartridges are fully double end‑capped to deliver:
Reduced silanol interactions
Improved peak shape for proteins, peptides, and large polar analytes
Consistent chromatographic protection in demanding analytical conditions
Each cartridge is constructed in a stainless steel body with stainless steel frits, secured with PEEK frit caps for durability and reliable sealing.
Designed for Analytical Columns (3.0–4.6 mm ID)
Compatible with:
3.0 mm ID solvent‑saving columns
4.0 mm ID analytical columns
4.6 mm ID standard HPLC columns
✅ Maintains method selectivity and chromatographic consistency
300 Å Wide Pore – Biomolecule Protection
Designed specifically for:
Proteins
Peptides
Large molecular weight compounds
Prevents:
Restricted diffusion
Pore blockage common with 100 Å media
✅ Essential for biomolecule and LC‑MS analytical workflows
Purpose of Guard Columns
Protect analytical columns from:
Particulate contamination
Strongly retained biomolecules
Sample matrix buildup and fouling
Extend column lifetime
Maintain retention time stability and peak shape
Reduce downtime and replacement costs
5 µm Guard Media – Balanced Performance & Compatibility
Matches standard analytical column particle size
Provides balanced efficiency and durability
Ideal for routine and biomolecule analytical workflows
✅ Delivers reliable protection without compromising chromatographic performance
Why Choose Wide Pore Guard Cartridges (5 µm, 300 Å)
Matched Biomolecule Chemistry
Same wide‑pore C18 chemistry as analytical columns
Maintains method integrity and selectivity
Prevents chromatographic variability
Enhanced Column Protection
Captures large and strongly retained compounds before reaching the column
Reduces fouling and long‑term degradation
Workflow Efficiency
Minimizes column downtime and replacement frequency
Supports high‑throughput analytical and LC‑MS laboratories
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Enhances reproducibility
High Purity Silica
Consistent chromatographic results
Reliable guard‑to‑guard performance
Durable Construction
Stainless steel cartridge body and frits
PEEK sealing system
Designed for routine analytical use
Important Usage Notes
⚠️ Must be used with a compatible guard column holder system
Designed for analytical HPLC systems (3.0–4.6 mm ID columns)
Replace regularly to maintain optimal chromatographic performance
Critical for protecting high‑value analytical columns