Catalog Number - 68522-10

68522-10 Cogent RP PFP™ HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for complex separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using ultra‑high purity silica.

The column enables multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. It is also suitable as an alternate column for USP methods requiring L43 classification.

With a 5 µm particle size, this column provides lower backpressure compared to smaller particle columns, allowing higher flow rates and robust, reproducible performance on standard analytical HPLC systems.

100 mm Length – Balanced Resolution and Efficiency

The 100 mm length offers an optimal balance between resolution and speed, making it ideal for routine analytical testing and method development.

• Improved resolution compared to 50 mm columns

• Faster run times than 150 mm or 250 mm columns

• Increased peak capacity for moderately complex samples

✅ Recommended for QA/QC laboratories and general analytical workflows

Flow Rate & System Requirements (4.6 mm ID, 5 µm)

⚠️ Fully compatible with standard analytical HPLC systems with manageable backpressure

• Typical flow rate range: ~1.0 – 1.5 mL/min

• Lower backpressure than 3 µm columns

• Supports stable, higher flow rate operation

• Compatible with UV and standard detectors

✅ Best Practice: Filter samples using a 0.2 µm syringe filter prior to injection

Why Choose PFP (F5) Columns for Selective Separations

Enhanced Retention for Halogenated Compounds

• Strong interaction with fluorinated and halogenated analytes

• Improved selectivity vs C18 columns

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Greater flexibility for method development

100 Å Pore Structure

• Suitable for small to moderately sized molecules

• Broader method applicability

Cogent RP PFP™ Column Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry

Robust Performance (5 µm Particles)

• Lower backpressure vs smaller particle sizes

• Reliable, consistent performance

High Purity Silica

• Reproducible chromatographic performance

• Long column lifetime

Typical Applications

• Halogenated compound analysis

• Aromatic compound separations

• Pharmaceutical QA/QC workflows

• Method development and optimization

• USP L43 methods

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Designed for standard analytical HPLC systems (4.6 mm ID)

• Lower backpressure compared to smaller particle columns

• Use 0.2 µm filtration prior to injection