Catalog Number - 68522-15P-2

68522-15P-2 Cogent RP PFP™ HPLC Column has been a premium value trusted by HPLC laboratories for many years, offering consistent performance and enhanced selectivity for complex analytical separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using ultra‑high purity silica.

The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it particularly effective for halogenated, aromatic, and polar analytes. It also serves as a suitable alternate column for USP methods requiring L43 classification.

With a 5 µm particle size, this column delivers lower backpressure than smaller particle columns, allowing improved system compatibility and robust operation while maintaining strong chromatographic performance.

150 mm Length – Enhanced Resolution for Analytical Separations

The 150 mm length provides increased resolving power compared to shorter columns, making it ideal for more complex separations.

• Higher resolution than 50 mm and 100 mm columns

• Improved separation of closely related analytes

• Increased peak capacity for more demanding samples

✅ Recommended for analytical methods requiring improved separation without maximum run times

Flow Rate & System Requirements (2.1 mm ID, 5 µm)

⚠️ Designed for low‑flow LC‑MS and analytical applications

• Typical flow rate range: ~0.2 – 0.4 mL/min

• Lower backpressure than 3 µm columns

• Compatible with LC‑MS and low‑flow HPLC systems

• Improved robustness for routine workflows

✅ Important: Standard HPLC systems must be capable of stable, accurate low flow rates

✅ Best Practice: Filter samples using a 0.2 µm syringe filter prior to injection

Why Choose PFP (F5) Columns for Selective Separations

Enhanced Retention for Halogenated Compounds

• Strong interaction with fluorinated and halogenated analytes

• Improved selectivity vs C18 columns

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Greater flexibility for method development

100 Å Pore Structure

• Suitable for small to moderately sized molecules

• Broad applicability across analytical methods

Cogent RP PFP™ Column Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry

Robust Performance (5 µm Particles)

• Lower backpressure vs smaller particle sizes

• Reliable and consistent operation

High Purity Silica

• Reproducible chromatographic performance

• Long column lifetime

Typical Applications

• Halogenated compound analysis

• Aromatic compound separations

• Polar analyte retention

• LC‑MS workflows

• Method development and optimization

• USP L43 methods

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Designed for LC‑MS and low‑flow HPLC systems (2.1 mm ID)

• Lower backpressure compared to smaller particle columns

• Requires accurate low‑flow pump capability

• Use 0.2 µm filtration prior to injection