Prep HPLC Column, RP PFP, 5um, 100A. 21.2mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
68522-P21-100 Cogent RP PFP™ Prep HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for preparative and scale‑up separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These interactions improve separation of structurally similar compounds, which is critical in preparative purification workflows.
With a 5 µm particle size, this column supports higher flow rates typical of preparative HPLC while maintaining strong efficiency and manageable system pressure.
100 mm Length – Balanced Resolution and Throughput
The 100 mm length offers an optimal balance between separation performance and run time for preparative workflows.
Improved resolution compared to 50 mm columns
Faster run times than longer preparative formats
Increased peak capacity for moderately complex mixtures
✅ Recommended for routine purification, scale‑up, and method optimization
Flow Rate & System Requirements (21.2 mm ID, 5 µm)
⚠️ Requires preparative HPLC system capability
Typical flow rate range: ~10 – 25 mL/min
Designed for high‑flow preparative operation
Moderate backpressure relative to column size
Compatible with fraction collectors and preparative detectors
✅ Important: A specialized preparative HPLC system is required for columns of this size
✅ Best Practice: Use appropriate sample filtration and a matched guard column to protect the prep column and maintain performance
Why Choose PFP (F5) Columns for Preparative Work
Enhanced Selectivity for Complex Mixtures
Strong interaction with halogenated and fluorinated compounds
Improved selectivity vs C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Greater flexibility for purification method development
100 Å Pore Structure
Suitable for small to moderately sized molecules
Consistent behavior from analytical to preparative scale
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and recovery
Optimized for Preparative Flow (5 µm Particles)
Supports high flow rates
Balanced efficiency and pressure
High Purity Silica
Reliable and reproducible chromatographic performance
Consistent results during scale‑up
Typical Applications
Preparative HPLC purification
Large‑scale compound isolation
Halogenated compound purification
Aromatic compound separations
Pharmaceutical scale‑up and impurity removal
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires preparative HPLC system capability
Designed for high‑flow operation (21.2 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable