Catalog Number - 68522-P30-150

68522-P30-150 Cogent RP PFP™ Prep HPLC Column has been a premium value trusted by HPLC laboratories for many years, providing reliable performance and enhanced selectivity for preparative and production‑scale separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.

The column delivers multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These interactions are essential for resolving closely related compounds and achieving high purity in large‑scale purification workflows.

With a 5 µm particle size, this column supports very high flow rates typical of 30 mm preparative systems while maintaining strong separation efficiency and manageable backpressure.

150 mm Length – Enhanced Resolution for Large‑Scale Purification

The 150 mm length provides increased resolving power compared to shorter preparative columns, making it ideal for more complex separations.

• Higher resolution than 50 mm and 100 mm columns

• Improved separation of closely related compounds

• Increased peak capacity for complex mixtures

✅ Recommended for purification workflows requiring improved separation at scale

Flow Rate & System Requirements (30 mm ID, 5 µm)

⚠️ Requires preparative or process‑scale HPLC system capability

• Typical flow rate range: ~20 – 50 mL/min

• Designed for very high‑flow preparative operation

• Moderate backpressure relative to column size

• Compatible with large‑scale fraction collection systems

✅ Important: A specialized preparative or process‑scale HPLC system is required for columns of this size

✅ Best Practice: Use appropriate sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain performance

Why Choose PFP (F5) Columns for Preparative Work

Enhanced Selectivity for Complex Mixtures

• Strong interaction with halogenated and fluorinated compounds

• Improved selectivity vs traditional C18 columns

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Greater flexibility for purification method development

100 Å Pore Structure

• Suitable for small to moderately sized molecules

• Consistent performance from analytical to large‑scale preparative systems

Cogent RP PFP™ Column Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry and recovery

Optimized for Preparative Flow (5 µm Particles)

• Supports very high flow rates

• Balanced efficiency and pressure for large-diameter columns

High Purity Silica

• Reliable and reproducible chromatographic performance

• Consistent purification results during scale‑up

Typical Applications

• Large‑scale preparative HPLC purification

• Process-scale compound isolation

• Halogenated compound purification

• Aromatic compound separations

• Pharmaceutical production and scale‑up

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Requires preparative or process‑scale HPLC system capability

Made‑to‑Order Columns & Pricing Information

This is a custom, made‑to‑order column.

• Columns are manufactured specifically to order

• Orders cannot be canceled once placed

• Custom columns are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification: Class A Custom Item

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.Designed for high‑flow operation (30 mm ID columns)