Process HPLC Column, RP PFP, 5um, 100A. 50mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
68522-P50-100 Cogent RP PFP™ Process HPLC Column has been a premium value trusted by HPLC laboratories for many years, providing reliable performance and enhanced selectivity for process‑scale and production‑level purification. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column delivers multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These interactions enable improved separation of structurally similar compounds, which is essential for consistent purity and yield in large‑scale operations.
With a 5 µm particle size, this column supports extremely high flow rates while maintaining strong chromatographic efficiency and manageable backpressure for large‑diameter process systems.
100 mm Length – Balanced Performance at Process Scale
The 100 mm length provides an ideal balance between resolution and throughput for production and scale‑up workflows.
Improved resolution compared to 50 mm process columns
Faster cycle times than longer column formats
Increased peak capacity for moderately complex mixtures
✅ Recommended for routine large‑scale purification and process optimization
Flow Rate & System Requirements (50 mm ID, 5 µm)
⚠️ Requires process‑scale or pilot‑scale HPLC system capability
Typical flow rate range: ~40 – 120 mL/min
Designed for extremely high‑flow operation
Moderate backpressure relative to column dimensions
Compatible with industrial fraction collection and process systems
✅ Important: A specialized process‑scale HPLC system is required for columns of this size
✅ Best Practice: Use appropriate sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain long-term performance
Why Choose PFP (F5) Columns for Process‑Scale Work
Enhanced Selectivity for Complex Mixtures
Strong interaction with halogenated and fluorinated analytes
Improved selectivity versus conventional C18 columns
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Greater flexibility for large‑scale purification method development
100 Å Pore Structure
Suitable for small to moderately sized molecules
Consistent performance from analytical to full process scale
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and compound recovery
Optimized for Process Flow (5 µm Particles)
Supports extremely high flow rates
Balanced efficiency and pressure for large‑diameter columns
High Purity Silica
Reliable and reproducible chromatographic performance
Consistent purification results in production environments
Typical Applications
Process‑scale HPLC purification
Pilot‑scale and production compound isolation
Halogenated compound purification
Aromatic compound separations
Pharmaceutical manufacturing and scale‑up
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires process‑scale HPLC system capability
Designed for ultra high‑flow operation (50 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable