Process HPLC Column, RP PFP, 5um, 100A. 50mm ID x 50mm Length. Cogent Brand. 1 EA.
Additional Info:
68522-P50-50 Cogent RP PFP™ Process HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering reliable performance and enhanced selectivity for large‑scale and production‑level purification. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using high purity 100 Å silica.
The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it highly effective for halogenated, aromatic, and polar analytes. These mechanisms support improved selectivity and purification efficiency for structurally similar compounds in process-scale workflows.
With a 5 µm particle size, this column supports very high flow rates while maintaining strong chromatographic efficiency and manageable pressure in large‑diameter HPLC systems.
50 mm Length – Fast Process‑Scale Purification
The 50 mm length is optimized for speed and throughput in production environments.
Rapid purification cycles and short run times
Reduced solvent consumption vs longer columns
Ideal for method scouting and production ramp‑up
✅ Recommended for high‑throughput purification and process development
Flow Rate & System Requirements (50 mm ID, 5 µm)
⚠️ Requires process‑scale or pilot‑scale HPLC system capability
Typical flow rate range: ~40 – 120 mL/min
Designed for extremely high‑flow operation
Moderate backpressure relative to column size
Compatible with large‑scale fraction collection and process systems
✅ Important: A specialized process‑scale HPLC system is required for columns of this size
✅ Best Practice: Use appropriate sample filtration and a matched RP PFP guard column cartridge to protect the column and maintain long-term performance
Why Choose PFP (F5) Columns for Process‑Scale Work
Enhanced Selectivity for Complex Mixtures
Strong interaction with halogenated and fluorinated compounds
Improved selectivity vs conventional C18 phases
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Greater flexibility in purification scale‑up
100 Å Pore Structure
Suitable for small to moderately sized molecules
Consistent performance from analytical to process scale
Cogent RP PFP™ Column Advantages
Fully End‑Capped Surface
Minimizes silanol activity
Improves peak symmetry and recovery
Optimized for Process Flow (5 µm Particles)
Supports extremely high flow rates
Balanced performance for large‑scale purification
High Purity Silica
Reliable and reproducible chromatographic performance
Consistent results in production environments
Typical Applications
Process‑scale HPLC purification
Pilot‑scale and production compound isolation
Halogenated compound purification
Aromatic compound separations
Pharmaceutical manufacturing and scale‑up
Important Usage Notes
Packed and shipped in reversed‑phase solvents
Requires process‑scale HPLC system capability
Designed for ultra high‑flow operation (50 mm ID columns)
Made‑to‑Order Columns & Pricing Information
This is a custom, made‑to‑order column.
Columns are manufactured specifically to order
Orders cannot be canceled once placed
Custom columns are non‑returnable